Polyubiquitinated RUNX3 translocates to the cytosol

Stable Identifier
R-HSA-8952399
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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Polyubiquitinated RUNX3 translocates to the cytosol
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Polyubiquitination of RUNX3 by MDM2 promotes translocation of RUNX3 from the nucleus to the cytosol (Chi et al. 2009).

Literature References
PubMed ID Title Journal Year
19808967 Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

Chi, XZ, Kim, J, Lee, YH, Lee, JW, Lee, KS, Wee, H, Kim, WJ, Park, WY, Oh, BC, Stein, GS, Ito, Y, van Wijnen, AJ, Bae, SC

Cancer Res. 2009
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Orthologous Events
Polyubiquitinated RUNX3 translocates to the cytosol (Bos taurus)
Polyubiquitinated RUNX3 translocates to the cytosol (Caenorhabditis elegans)
Polyubiquitinated RUNX3 translocates to the cytosol (Canis familiaris)
Polyubiquitinated RUNX3 translocates to the cytosol (Danio rerio)
Polyubiquitinated RUNX3 translocates to the cytosol (Drosophila melanogaster)
Polyubiquitinated RUNX3 translocates to the cytosol (Gallus gallus)
Polyubiquitinated RUNX3 translocates to the cytosol (Mus musculus)
Polyubiquitinated RUNX3 translocates to the cytosol (Rattus norvegicus)
Polyubiquitinated RUNX3 translocates to the cytosol (Sus scrofa)
Polyubiquitinated RUNX3 translocates to the cytosol (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-15)