Polyubiquitinated RUNX3 is degraded by the proteasome

Stable Identifier
R-HSA-8952408
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Polyubiquitinated RUNX3 is degraded by the proteasome
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Polyubiquitinated RUNX3 is degraded by the proteasome (Chi et al. 2009).

Literature References
PubMed ID Title Journal Year
19808967 Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination

Chi, XZ, Kim, J, Lee, YH, Lee, JW, Lee, KS, Wee, H, Kim, WJ, Park, WY, Oh, BC, Stein, GS, Ito, Y, van Wijnen, AJ, Bae, SC

Cancer Res. 2009
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [nucleoplasm]
Physical Entity
26S proteasome [nucleoplasm]
Activity
endopeptidase activity (0004175)
Orthologous Events
Polyubiquitinated RUNX3 is degraded by the proteasome (Bos taurus)
Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)
Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)
Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)
Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)
Polyubiquitinated RUNX3 is degraded by the proteasome (Sus scrofa)
Polyubiquitinated RUNX3 is degraded by the proteasome (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-15)