SMURFs ubiquitinate RUNX3

Stable Identifier
R-HSA-8952419
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SMURF1 and SMURF2 polyubiquitinate RUNX3 on unknown lysine residues, possibly K148, K186 and K192, targeting it for degradation. The interaction between SMURFs and RUNX3 involves the PY motif of RUNX3 and the WW domain of SMURFs. Acetylation of RUNX3 by EP300 (p300) prevents SMURF-mediated ubiquitination of RUNX3, thus increasing RUNX3 protein stability (Jin et al. 2004).

Literature References
PubMed ID Title Journal Year
15138260 Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation

Jin, YH, Jeon, EJ, Li, QL, Lee, YH, Choi, JK, Kim, WJ, Lee, KY, Bae, SC

J. Biol. Chem. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of SMURF [nucleoplasm]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created