SPP1 gene expression is stimulated by RUNX3

Stable Identifier
R-HSA-8952442
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SPP1 gene expression is stimulated by RUNX3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Both human and mouse SPP1 (osteopontin) gene promoters contain Runx and SMAD response elements. Transcription of SPP1 increases in response to increased RUNX3 levels, which contributes to invasiveness of pancreatic cancer cells. Direct binding of RUNX3 to the SPP1 promoter has not been examined (Whittle et al. 2015).

Literature References
PubMed ID Title Journal Year
26004068 RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma

Whittle, MC, Izeradjene, K, Rani, PG, Feng, L, Carlson, MA, DelGiorno, KE, Wood, LD, Goggins, M, Hruban, RH, Chang, AE, Calses, P, Thorsen, SM, Hingorani, SR

Cell 2015
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Positively by
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-16)