Both human and mouse SPP1 (osteopontin) gene promoters contain Runx and SMAD response elements. Transcription of SPP1 increases in response to increased RUNX3 levels, which contributes to invasiveness of pancreatic cancer cells. Direct binding of RUNX3 to the SPP1 promoter has not been examined (Whittle et al. 2015).
Whittle, MC, Izeradjene, K, Rani, PG, Feng, L, Carlson, MA, DelGiorno, KE, Wood, LD, Goggins, M, Hruban, RH, Chang, AE, Calses, P, Thorsen, SM, Hingorani, SR
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