Reactome | AcM-UBE2M [nucleoplasm]

AcM-UBE2M [nucleoplasm]

Stable Identifier

R-HSA-8952502

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NEDD8-conjugating enzyme Ubc12, UBC12_HUMAN

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External Reference Information

External Reference

UniProt:P61081 UBE2M

Gene Names

UBE2M, UBC12

Chain

chain:1-183

Reference Genes

BioGPS Gene:9040 UBE2M

COSMIC (genes):UBE2M UBE2M

CTD Gene:9040 UBE2M

dbSNP Gene:9040 UBE2M

ENSEMBL:ENSG00000130725 UBE2M

ENSEMBL_homo_sapiens_GENE:ENSG00000130725.8 UBE2M

HGNC:12491 UBE2M

KEGG Gene (Homo sapiens):9040 UBE2M

Monarch:9040 UBE2M

NCBI Gene:9040 UBE2M

OMIM:603173 UBE2M

UCSC:P61081 UBE2M

Reference Transcript

RefSeq:NM_003969.3 UBE2M

Other Identifiers

11722192_s_at

16876191

203109_PM_at

203109_at

33781_s_at

33782_r_at

3689612

3689615

3689616

3689617

3689618

3873000

3873001

3873002

3873004

3873006

3873007

3873009

3873011

3873012

3873013

3873014

3873015

8039805

9040

A_23_P141847

GE79231

GO:0000166

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0012501

GO:0016740

GO:0019787

GO:0019788

GO:0032446

GO:0036211

GO:0043226

GO:0043525

GO:0043687

GO:0045116

GO:0061654

GO:0140096

ILMN_1701331

PH_hs_0030050

TC19001923.hg

g4507790_3p_at

Participates

as an output of

AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)

Other forms of this molecule

G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]

UBE2M [cytosol]

AcM-UBE2M [cytosol]

G76-NEDD8-C111-AcM-UBE2M [cytosol]

Inferred To

UbcE2M [nucleoplasm] (Drosophila melanogaster)

Ube2m [nucleoplasm] (Mus musculus)

Ube2m [nucleoplasm] (Rattus norvegicus)

AcM-UBE2M [nucleoplasm] (Gallus gallus)

ube2m [nucleoplasm] (Dictyostelium discoideum)

ube2m [nucleoplasm] (Xenopus tropicalis)

ubc12 [nucleoplasm] (Schizosaccharomyces pombe)

UBE2M [nucleoplasm] (Bos taurus)

UBE2M [nucleoplasm] (Canis familiaris)

UBE2M [nucleoplasm] (Sus scrofa)

Modified Residues

Name

N-acetyl-L-methionine at 1

Coordinate

PsiMod Name

N-acetyl-L-methionine [MOD:00058]

PsiMod Definition

A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine.

Cross References

RefSeq

NP_003960.1

OpenTargets

ENSG00000130725

HPA

ENSG00000130725-UBE2M

GeneCards

P61081

Ensembl

ENSP00000253023, ENST00000253023, ENSG00000130725

PRO

P61081

Pharos - Targets

P61081

HMDB Protein

HMDBP00563

PDB

3TDZ, 4GAO, 4P5O, 3TDU, 2NVU, 1Y8X, 1TT5

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.936	11
UniProt:Q8TBC4 UBA3	2	UBA3 [cytosol] (R-HSA-947632) G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640)	0.825	5
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.786	5
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.754	7
UniProt:Q96GG9 DCUN1D1	2	DCUN1D1 [nucleoplasm] (R-HSA-8952487) DCUN1D1 [cytosol] (R-HSA-8951781)	0.744	5
UniProt:Q13564 NAE1	1	NAE1 [cytosol] (R-HSA-8951449)	0.744	4
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.643	3
UniProt:O60260-5 PRKN			0.556	3
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.556	3
UniProt:Q9P2K6 KLHL42	1	KLHL42 [cytosol] (R-HSA-8863204)	0.527	2
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.527	2
UniProt:Q8TBC3 SHKBP1	1	SHKBP1 [cytosol] (R-HSA-9714849)	0.527	2
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.527	2
UniProt:Q9H9Q2 COPS7B	2	COPS7B [cytosol] (R-HSA-416966) COPS7B [nucleoplasm] (R-HSA-5697023)	0.527	2
UniProt:Q9BT78 COPS4	2	COPS4 [nucleoplasm] (R-HSA-5697020) COPS4 [cytosol] (R-HSA-416965)	0.527	2
UniProt:Q9Y2I1 NISCH	1	NISCH [cytosol] (R-HSA-9691384)	0.527	2
UniProt:Q9H0C5 BTBD1	1	BTBD1 [cytosol] (R-HSA-8851650)	0.527	2
UniProt:Q86V97 KBTBD6	1	KBTBD6 [cytosol] (R-HSA-8863221)	0.527	2
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.527	2
UniProt:O94844 RHOBTB1	1	RHOBTB1 [endosome membrane] (R-HSA-194899)	0.527	2
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.527	2

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