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G76-NEDD8-K705-CUL4A [nucleoplasm]
Stable Identifier
R-HSA-8952514
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-4A, CUL4A_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
NEDD8:CUL4 [nucleoplasm] (Homo sapiens)
NEDD8-CUL4A [nucleoplasm] (Homo sapiens)
G76-NEDD8-K705-CUL4A [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
NEDD8:CUL4 [nucleoplasm] (Homo sapiens)
NEDD8-CUL4A [nucleoplasm] (Homo sapiens)
G76-NEDD8-K705-CUL4A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13619 CUL4A
Gene Names
CUL4A
Chain
chain:1-759
Reference Genes
BioGPS Gene:8451 CUL4A
COSMIC (genes):CUL4A CUL4A
CTD Gene:8451 CUL4A
dbSNP Gene:8451 CUL4A
ENSEMBL:ENSG00000139842 CUL4A
HGNC:2554 CUL4A
KEGG Gene (Homo sapiens):8451 CUL4A
Monarch:8451 CUL4A
NCBI Gene:8451 CUL4A
OMIM:603137 CUL4A
UCSC:Q13619 CUL4A
Reference Transcript
RefSeq:NM_003589.2 CUL4A
RefSeq:NM_001008895.2 CUL4A
RefSeq:NM_001278513.1 CUL4A
RefSeq:XM_011537523.2 CUL4A
Other Identifiers
0006370020
11743766_a_at
11748671_a_at
11752001_a_at
16776827
201423_s_at
201424_s_at
3502499
3502500
3502501
3502503
3502504
3502506
3502507
3502510
3502511
3502512
3502515
3502517
3502521
3502523
3502527
3502534
3502537
3502538
3502543
3502545
3502546
3502547
3502549
3502550
3502552
3502557
3502558
3502559
3502560
3502561
3502563
3502564
40908_r_at
7970262
8451
A_23_P151471
A_24_P61467
A_33_P3322909
GE873867
GO:0000082
GO:0000278
GO:0000715
GO:0000717
GO:0001701
GO:0002376
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006259
GO:0006281
GO:0006283
GO:0006293
GO:0006294
GO:0006295
GO:0006296
GO:0006464
GO:0006511
GO:0006950
GO:0006974
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009056
GO:0009790
GO:0016032
GO:0016567
GO:0019005
GO:0019899
GO:0022607
GO:0030097
GO:0030154
GO:0030853
GO:0031146
GO:0031461
GO:0031464
GO:0031625
GO:0032991
GO:0033683
GO:0034641
GO:0035019
GO:0042254
GO:0042769
GO:0043161
GO:0043226
GO:0043687
GO:0044403
GO:0048511
GO:0048856
GO:0051246
GO:0051276
GO:0065003
GO:0070911
GO:0080008
GO:0097193
GO:1900087
GO:2000001
GO:2000819
Hs.183874.0.A1_3p_a_at
ILMN_1686156
ILMN_1695792
ILMN_2331163
PH_hs_0023344
TC13000419.hg
U58090_at
g11140810_3p_a_at
Participant Of
hasComponent
NEDD8-CUL4A [nucleoplasm]
Other forms of this molecule
CUL4A [nucleoplasm]
Inferred To
pcu4 [nucleoplasm] (Schizosaccharomyces pombe)
cul-4 [nucleoplasm] (Caenorhabditis elegans)
CUL4A [nucleoplasm] (Canis familiaris)
CUL4A [nucleoplasm] (Gallus gallus)
CUL4A [nucleoplasm] (Sus scrofa)
cul4a [nucleoplasm] (Danio rerio)
cul4a [nucleoplasm] (Xenopus tropicalis)
culD [nucleoplasm] (Dictyostelium discoideum)
Cul4 [nucleoplasm] (Drosophila melanogaster)
Cul4a [nucleoplasm] (Mus musculus)
Cul4a [nucleoplasm] (Rattus norvegicus)
G76-NEDD8-K705-CUL4A [nucleoplasm] (Bos taurus)
Modified Residues
Name
Inter-chain Crosslink via neddylated lysine at 705 and 76
Coordinate
705
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
XP_011535825.1
,
NP_001008895.1
,
NP_003580.1
,
NP_001265442.1
OpenTargets
ENSG00000139842
HPA
ENSG00000139842-CUL4A
GeneCards
Q13619
Ensembl
ENST00000375441
,
ENSP00000389118
,
ENST00000617546
,
ENST00000375440
,
ENSP00000364589
,
ENSP00000481782
,
ENSG00000139842
,
ENSP00000364590
,
ENST00000451881
PRO
Q13619
Orphanet
25733
PDB
2HYE
,
4A0K
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92466 DDB2
3
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
0.823
10
UniProt:Q86VP6 CAND1
5
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [nucleoplasm]
(R-HSA-8955089)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [cytosol]
(R-HSA-5691146)
0.723
6
UniProt:O94888 UBXN7
1
UBXN7 [cytosol]
(R-HSA-8956071)
0.623
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:Q96SW2 CRBN
1
CRBN [cytosol]
(R-HSA-8863300)
0.528
5
UniProt:Q15843 NEDD8
17
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
K1881-CUL9-G76-NEDD8 [cytosol]
(R-HSA-8955924)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
K705-CUL4A-G76-NEDD8 [nucleoplasm]
(R-HSA-8952528)
K859-CUL4B-G76-NEDD8 [nucleoplasm]
(R-HSA-8952538)
NEDD8(77-88) [cytosol]
(R-HSA-6782654)
NEDD8(1-88) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
K720-CUL1-G76-NEDD8 [cytosol]
(R-HSA-8952534)
K712-CUL3-G76-NEDD8 [cytosol]
(R-HSA-8952531)
K689-CUL2-G76-NEDD8 [cytosol]
(R-HSA-8952526)
K724-CUL5-G76-NEDD8 [cytosol]
(R-HSA-8952018)
NEDD8 [cytosol]
(R-HSA-416969)
K567-TGFBR2-G76-NEDD8 [cytosol]
(R-HSA-4419906)
K556-TGFBR2-G76-NEDD8 [cytosol]
(R-HSA-4419907)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
8
UniProt:Q8NHY2 COP1
3
RFWD2 [nucleoplasm]
(R-HSA-349454)
p-S387-RFWD2 [cytosol]
(R-HSA-349439)
p-S387-RFWD2 [nucleoplasm]
(R-HSA-349450)
0.527
4
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [cytosol]
(R-HSA-1181251)
0.499
2
UniProt:Q15291 RBBP5
1
RBBP5 [nucleoplasm]
(R-HSA-1629836)
0.499
3
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