G76-NEDD8-K705-CUL4A [nucleoplasm]

Stable Identifier
R-HSA-8952514
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-4A, CUL4A_HUMAN
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q13619 CUL4A
Gene Names
CUL4A
Chain
chain:1-759
Reference Genes
BioGPS Gene:8451 CUL4A
COSMIC (genes):CUL4A CUL4A
CTD Gene:8451 CUL4A
dbSNP Gene:8451 CUL4A
ENSEMBL:ENSG00000139842 CUL4A
HGNC:2554 CUL4A
KEGG Gene (Homo sapiens):8451 CUL4A
Monarch:8451 CUL4A
NCBI Gene:8451 CUL4A
OMIM:603137 CUL4A
UCSC:Q13619 CUL4A
Reference Transcript
Other Identifiers
0006370020
11743766_a_at
11748671_a_at
11752001_a_at
16776827
201423_s_at
201424_s_at
2HYE
3502499
3502500
3502501
3502503
3502504
3502506
3502507
3502510
3502511
3502512
3502515
3502517
3502521
3502523
3502527
3502534
3502537
3502538
3502543
3502545
3502546
3502547
3502549
3502550
3502552
3502557
3502558
3502559
3502560
3502561
3502563
3502564
40908_r_at
4A0K
58979
7970262
8451
A0A087WWN2
A0A0A0MR50
A_23_P151471
A_24_P61467
A_33_P3322909
AAC50547
AAD45191
AAH08308
AAR13072
AB012193
AB178950
AF077188
AL136221
AY365124
BAA33146
BAD93235
BC008308
CCDS41908
CCDS9533
CUL4A
CUL4A-202
CUL4A-203
CUL4A-204
CUL4A-212
ENSG00000139842
ENSP00000364589
ENSP00000364590
ENSP00000389118
ENSP00000481782
ENST00000375440
ENST00000375440.8
ENST00000375441
ENST00000375441.7
ENST00000451881
ENST00000451881.5
ENST00000617546
ENST00000617546.4
EntrezGene:8451
EntrezGene:CUL4A
g11140810_3p_a_at
GE873867
GO:0000082
GO:0000278
GO:0000715
GO:0000717
GO:0001701
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0006259
GO:0006281
GO:0006283
GO:0006293
GO:0006294
GO:0006295
GO:0006296
GO:0006464
GO:0006511
GO:0006950
GO:0006974
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009056
GO:0009790
GO:0016032
GO:0016567
GO:0019005
GO:0019899
GO:0022607
GO:0030097
GO:0030154
GO:0030853
GO:0031146
GO:0031461
GO:0031464
GO:0031625
GO:0032991
GO:0033683
GO:0034641
GO:0035019
GO:0042254
GO:0042769
GO:0043161
GO:0043226
GO:0043687
GO:0044403
GO:0048511
GO:0048856
GO:0051246
GO:0051276
GO:0065003
GO:0070911
GO:0080008
GO:0097193
GO:1900087
GO:2000001
GO:2000819
HGNC:2554
HPA058979
Hs.183874.0.A1_3p_a_at
ILMN_1686156
ILMN_1695792
ILMN_2331163
IPR001373
IPR016157
IPR016158
IPR016159
IPR019559
IPR036317
IPR036388
IPR036390
MIM:603137
NM_001008895
NM_001278513
NM_001354938
NM_001354939
NM_001354940
NM_001354941
NM_001354942
NM_003589
NP_001008895
NP_001265442
NP_001341867
NP_001341868
NP_001341869
NP_001341870
NP_001341871
NP_003580
PF00888
PF10557
PH_hs_0023344
SM00182
SM00884
TC13000419.hg
U58090
U58090_at
UPI00001286A5
UPI000021C449
XM_011537523
XP_011535825
Participant Of
hasComponent
Other forms of this molecule
CUL4A [nucleoplasm]
Inferred To
cul-4 [nucleoplasm] (Caenorhabditis elegans)
CUL4A [nucleoplasm] (Bos taurus)
CUL4A [nucleoplasm] (Canis familiaris)
CUL4A [nucleoplasm] (Sus scrofa)
cul4a [nucleoplasm] (Xenopus tropicalis)
culD [nucleoplasm] (Dictyostelium discoideum)
Cul4 [nucleoplasm] (Drosophila melanogaster)
Cul4a [nucleoplasm] (Mus musculus)
Cul4a [nucleoplasm] (Rattus norvegicus)
G76-NEDD8-K705-CUL4A [nucleoplasm] (Danio rerio)
cul3 [nucleoplasm] (Schizosaccharomyces pombe)
Modified Residues
Name
Inter-chain Crosslink via neddylated lysine at 705 and 76
Coordinate
705
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
OpenTargets
HPA
GeneCards
Ensembl
PRO
Orphanet
PDB
Interactors (8)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q92466 DDB2  3 0.823 10
 UniProt:Q86VP6 CAND1  5 0.723 6
 UniProt:O94888 UBXN7  1 0.623 7
 UniProt:P08238 HSP90AB1  6 0.564 2
 UniProt:Q15843 NEDD8  17 0.527 8
 UniProt:Q8NHY2 COP1  3 0.527 4
 UniProt:Q15291 RBBP5  1 0.499 3
 UniProt:P55072 VCP  8 0.499 2
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