Reactome | G76-NEDD8-K705-CUL4A [nucleoplasm]

G76-NEDD8-K705-CUL4A [nucleoplasm]

Stable Identifier

R-HSA-8952514

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cullin-4A, CUL4A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13619 CUL4A

Gene Names

CUL4A

Chain

chain:1-759

Reference Genes

BioGPS Gene:8451 CUL4A

COSMIC (genes):CUL4A CUL4A

CTD Gene:8451 CUL4A

dbSNP Gene:8451 CUL4A

ENSEMBL:ENSG00000139842 CUL4A

HGNC:2554 CUL4A

KEGG Gene (Homo sapiens):8451 CUL4A

Monarch:8451 CUL4A

NCBI Gene:8451 CUL4A

OMIM:603137 CUL4A

UCSC:Q13619 CUL4A

Reference Transcript

Other Identifiers

0006370020

11743766_a_at

11748671_a_at

11752001_a_at

16776827

201423_s_at

201424_s_at

3502499

3502500

3502501

3502503

3502504

3502506

3502507

3502510

3502511

3502512

3502515

3502517

3502521

3502523

3502527

3502534

3502537

3502538

3502543

3502545

3502546

3502547

3502549

3502550

3502552

3502557

3502558

3502559

3502560

3502561

3502563

3502564

40908_r_at

7970262

8451

A_23_P151471

A_24_P61467

A_33_P3322909

GE873867

GO:0000082

GO:0000278

GO:0000715

GO:0000717

GO:0001701

GO:0002376

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006259

GO:0006281

GO:0006283

GO:0006293

GO:0006294

GO:0006295

GO:0006296

GO:0006464

GO:0006511

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009056

GO:0009790

GO:0016032

GO:0016567

GO:0019005

GO:0019899

GO:0022607

GO:0030097

GO:0030154

GO:0030853

GO:0031146

GO:0031461

GO:0031464

GO:0031625

GO:0032991

GO:0033683

GO:0034641

GO:0035019

GO:0042254

GO:0042769

GO:0043161

GO:0043226

GO:0043687

GO:0044403

GO:0048511

GO:0048856

GO:0051246

GO:0051276

GO:0065003

GO:0070911

GO:0080008

GO:0097193

GO:1900087

GO:2000001

GO:2000819

Hs.183874.0.A1_3p_a_at

ILMN_1686156

ILMN_1695792

ILMN_2331163

PH_hs_0023344

TC13000419.hg

U58090_at

g11140810_3p_a_at

Participant Of

hasComponent

NEDD8-CUL4A [nucleoplasm]

Other forms of this molecule

CUL4A [nucleoplasm]

Inferred To

pcu4 [nucleoplasm] (Schizosaccharomyces pombe)

cul-4 [nucleoplasm] (Caenorhabditis elegans)

CUL4A [nucleoplasm] (Canis familiaris)

CUL4A [nucleoplasm] (Gallus gallus)

CUL4A [nucleoplasm] (Sus scrofa)

cul4a [nucleoplasm] (Danio rerio)

cul4a [nucleoplasm] (Xenopus tropicalis)

culD [nucleoplasm] (Dictyostelium discoideum)

Cul4 [nucleoplasm] (Drosophila melanogaster)

Cul4a [nucleoplasm] (Mus musculus)

Cul4a [nucleoplasm] (Rattus norvegicus)

G76-NEDD8-K705-CUL4A [nucleoplasm] (Bos taurus)

Modified Residues

Name

Inter-chain Crosslink via neddylated lysine at 705 and 76

Coordinate

705

PsiMod Name

neddylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.

Cross References

RefSeq

XP_011535825.1, NP_001008895.1, NP_003580.1, NP_001265442.1

OpenTargets

ENSG00000139842

HPA

ENSG00000139842-CUL4A

GeneCards

Q13619

Ensembl

ENST00000375441, ENSP00000389118, ENST00000617546, ENST00000375440, ENSP00000364589, ENSP00000481782, ENSG00000139842, ENSP00000364590, ENST00000451881

PRO

Q13619

Orphanet

25733

PDB

2HYE, 4A0K

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92466 DDB2	3	DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654) PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035)	0.823	10
UniProt:Q86VP6 CAND1	5	CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [nucleoplasm] (R-HSA-8955089) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [cytosol] (R-HSA-5691146)	0.723	6
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.623	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.528	5
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	8
UniProt:Q8NHY2 COP1	3	RFWD2 [nucleoplasm] (R-HSA-349454) p-S387-RFWD2 [cytosol] (R-HSA-349439) p-S387-RFWD2 [nucleoplasm] (R-HSA-349450)	0.527	4
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [cytosol] (R-HSA-1181251)	0.499	2
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.499	3

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