Reactome | G76-NEDD8-K712-CUL3 [cytosol]

G76-NEDD8-K712-CUL3 [cytosol]

Stable Identifier

R-HSA-8952516

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cullin-3, CUL3_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Homo sapiens)
        
        KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
        
        KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
        
        G76-NEDD8-K712-CUL3 [cytosol] (Homo sapiens)
        
        NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
        
        KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Homo sapiens)
        
        KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
        
        G76-NEDD8-K712-CUL3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13618 CUL3

Gene Names

CUL3, KIAA0617

Chain

initiator methionine:, chain:2-768

Reference Genes

BioGPS Gene:8452 CUL3

COSMIC (genes):CUL3 CUL3

CTD Gene:8452 CUL3

dbSNP Gene:8452 CUL3

ENSEMBL:ENSG00000036257 CUL3

HGNC:2553 CUL3

KEGG:hsa:8452 CUL3

Monarch:8452 CUL3

NCBI Gene:8452 CUL3

OMIM:603136 CUL3

UCSC:Q13618 CUL3

Reference Transcript

Participates

as a component of

Other forms of this molecule

CUL3 [cytosol]

CUL3 [nucleoplasm]

Inferred To

Ghost homologue of G76-NEDD8-K712-CUL3 [cytosol] (Plasmodium falciparum)

cul3 [cytosol] (Schizosaccharomyces pombe)

cul3 [cytosol] (Xenopus tropicalis)

CUL3 [cytosol] (Bos taurus)

CUL3 [cytosol] (Canis familiaris)

CUL3 [cytosol] (Saccharomyces cerevisiae)

CUL3 [cytosol] (Sus scrofa)

cul3b [cytosol] (Danio rerio)

Cul3 [cytosol] (Drosophila melanogaster)

Cul3 [cytosol] (Mus musculus)

Cul3 [cytosol] (Rattus norvegicus)

G76-NEDD8-K712-CUL3 [cytosol] (Gallus gallus)

cul-3 [cytosol] (Caenorhabditis elegans)

culC [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

neddylated lysine (monoNEDD8 [cytosol]) at 712

Coordinate

712

Modification

monoNEDD8 [cytosol]

PsiMod Name

neddylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.

Cross References

OpenTargets

ENSG00000036257

ENSEMBL

ENST00000409777, ENSP00000386525, ENST00000409096, ENST00000264414, ENSP00000264414, ENST00000344951, ENSP00000343601, ENSG00000036257, ENSP00000387200

GeneCards

CUL3

HPA

ENSG00000036257-CUL3

PRO

Q13618

Pharos - Targets

Q13618

GlyGen

Q13618

Orphanet

CUL3

HMDB Protein

HMDBP12790

PDB

8H35, 8H37, 8H33, 8H36, 4EOZ, 8I79, 6I2M, 2MYM, 2MYL, 8H34, 4AP2, 8K8T, 5NLB, 8U82, 8U80, 8H38, 8U84, 4HXI, 4APF, 8H3F, 8H3A, 8K9I, 8H3R, 8U81, 8U83, 8H3Q, 8KHP, 8GQ6

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.871	13
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.819	7
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [nucleoplasm] (R-HSA-8955089)	0.748	8
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.725	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.723	4
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.666	5
UniProt:O94955 RHOBTB3	1	RHOBTB3 [trans-Golgi network membrane] (R-HSA-6813908)	0.643	4
UniProt:O94888 WIPF1	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.623	6
UniProt:Q14790 CASP8	8	CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(1-374) [cytosol] (R-HSA-3465404)	0.602	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q15369 ELOC	2	ELOC [cytosol] (R-HSA-180535) TCEB1 [nucleoplasm] (R-HSA-112422)	0.547	3
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	2
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.527	2
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.527	2
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.527	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	2
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.527	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	2
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	2
UniProt:Q13427 PPIG	2	PPIG [nucleoplasm] (R-HSA-9769592) PPIG [cytosol] (R-HSA-9728768)	0.527	2
UniProt:P78527 PRKDC	4	p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.527	2
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530)	0.527	2
UniProt:P62937 PPIA	5	PPIA [cytosol] (R-HSA-173123) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [extracellular region] (R-HSA-173646) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [extracellular exosome] (R-HSA-6801538)	0.527	2
UniProt:P07737 PFN1	2	PFN1 [cytosol] (R-HSA-203081) PFN1 [extracellular region] (R-HSA-350755)	0.527	2
UniProt:P55265 ADAR	2	ADAR1 [cytosol] (R-HSA-9835955) ADAR [nucleoplasm] (R-HSA-53939)	0.527	2
UniProt:Q9BYZ6 RHOBTB2	1	RHOBTB2 [endosome membrane] (R-HSA-194907)	0.527	2
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.527	4
UniProt:O94844 RHOBTB1	1	RHOBTB1 [endosome membrane] (R-HSA-194899)	0.527	5
UniProt:P22314 UBA1	2	UBA1 [cytosol] (R-HSA-947698) UBA1 [nucleoplasm] (R-HSA-8852116)	0.527	2
UniProt:Q8IWE4 DCUN1D3	2	MyrG-DCUN1D3 [plasma membrane] (R-HSA-8956204) DCUN1D3 [cytosol] (R-HSA-8951782)	0.499	2

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