Reactome | G76-NEDD8-K720-CUL1 [cytosol]

G76-NEDD8-K720-CUL1 [cytosol]

Stable Identifier

R-HSA-8952519

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cul1

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External Reference Information

External Reference

UniProt:Q13616 CUL1

Gene Names

CUL1

Chain

chain:1-776

Reference Genes

BioGPS Gene:8454 CUL1

COSMIC (genes):CUL1 CUL1

CTD Gene:8454 CUL1

dbSNP Gene:8454 CUL1

ENSEMBL:ENSG00000055130 CUL1

HGNC:2551 CUL1

KEGG:hsa:8454 CUL1

Monarch:8454 CUL1

NCBI Entrez Gene:8454 CUL1

OMIM:603134 CUL1

UCSC:Q13616 CUL1

Reference Transcript

Other Identifiers

11716819_a_at

11747353_a_at

17053019

207614_PM_s_at

207614_s_at

2874246

3030286

3030287

3030288

3030289

3030290

3030291

3030292

3030298

3030299

3030300

3030301

3030302

3030309

3030312

3030313

3030314

3030315

3030316

3030317

3030318

3030320

3030321

3030337

3030338

3030339

3030340

3030342

3030343

3030345

3030349

3030354

3030355

3030357

3030359

3030361

3030362

3030363

3030369

39723_at

39724_s_at

8137054

8454

A_14_P122956

A_14_P130379

A_23_P59657

A_24_P303589

GE54578

GO:0000045

GO:0000082

GO:0000209

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006511

GO:0006513

GO:0006915

GO:0007040

GO:0008283

GO:0009887

GO:0010498

GO:0010507

GO:0010508

GO:0016567

GO:0019005

GO:0030163

GO:0030674

GO:0031146

GO:0031461

GO:0031625

GO:0031669

GO:0034599

GO:0038202

GO:0043123

GO:0043124

GO:0043161

GO:0060090

GO:0070936

GO:0097193

GO:0140374

GO:0160072

GO:1904037

GO:1904262

GO:1990452

HMNXSV003016400

ILMN_1749629

PH_hs_0023905

TC07000969.hg

U58087_at

g4503160_3p_a_at

Participates

as a component of

NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)

Other forms of this molecule

CUL1 [cytosol]

CUL1 [nucleoplasm]

Inferred To

Cul1 [cytosol] (Drosophila melanogaster)

Cul1 [cytosol] (Mus musculus)

Cul1 [cytosol] (Rattus norvegicus)

cul1a [cytosol] (Danio rerio)

culB [cytosol] (Dictyostelium discoideum)

cul1 [cytosol] (Xenopus tropicalis)

CUL1 [cytosol] (Bos taurus)

CUL1 [cytosol] (Canis familiaris)

CUL1 [cytosol] (Gallus gallus)

CUL1 [cytosol] (Sus scrofa)

cul-1 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

neddylated lysine (monoNEDD8 [cytosol]) at 720

Coordinate

720

Modification

monoNEDD8 [cytosol]

PsiMod Name

neddylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.

Cross References

RefSeq

NP_001357589.1, NP_001357591.1, XP_011514932.1, NP_001357592.1, NP_001357593.1, NP_003583.2, XP_005250117.1, XP_011514934.1, XP_011514933.1, XP_011514931.1, NP_001357590.1

OpenTargets

ENSG00000055130

ENSEMBL

ENST00000665936, ENST00000662716, ENSP00000387160, ENSP00000499398, ENSP00000499255, ENST00000602748, ENSP00000499277, ENST00000663044, ENSP00000473318, ENST00000325222, ENSP00000326804, ENSG00000055130, ENST00000409469

GeneCards

CUL1

HPA

ENSG00000055130-CUL1

PRO

Q13616

Pharos - Targets

Q13616

GlyGen

Q13616

PDB

6TTU, 7Z8T, 7Z8R, 4P5O, 3TDZ, 7B5M, 7B5L, 7B5S, 8VVY, 7Z8V, 7B5N, 8OR3, 8UBT, 8OR4, 8CAF, 9KBD, 8OR0, 8OR2, 7B5R, 3RTR, 1LDK, 1LDJ, 4F52, 8UBU, 8UA6, 9JKB, 1U6G, 5V89, 6WCQ, 7ZBZ, 7ZBW, 8CDJ, 8CDK, 3TDU

Interactors (76)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.978	31
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.961	23
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.959	21
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [nucleoplasm] (R-HSA-8955089)	0.956	33
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.932	15
UniProt:Q9UKB1 FBXW11	2	FBXW11 [nucleoplasm] (R-HSA-9953055) FBXW11 [cytosol] (R-HSA-976035)	0.928	14
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.919	11
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.855	13
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.823	15
UniProt:Q9UKT5 FBXO4	1	FBXO4 [cytosol] (R-HSA-391298)	0.813	6
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.812	9
UniProt:Q9NRD1 FBXO6	1	FBXO6 [cytosol] (R-HSA-391296)	0.802	6
UniProt:Q96EF6 FBXO17	1	FBXO17 [cytosol] (R-HSA-976036)	0.794	11
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.788	9
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502)	0.786	5
UniProt:Q92905 COPS5	3	COPS5 [nucleoplasm] (R-HSA-5697019) CSN5 [cytosol] (R-HSA-9929354) COPS5 [cytosol] (R-HSA-416963)	0.783	15
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.773	9
UniProt:Q8N1E6 FBXL14	1	FBXL14 [cytosol] (R-HSA-8862603)	0.758	7
UniProt:Q9UK99 FBX3			0.737	10
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.69	12
UniProt:Q6P3S6 FBX42			0.69	9
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.688	6
UniProt:Q96GG9 DCUN1D1	2	DCUN1D1 [cytosol] (R-HSA-8951781) DCUN1D1 [nucleoplasm] (R-HSA-8952487)	0.669	7
UniProt:P41002 CCNF	1	CCNF [cytosol] (R-HSA-8862602)	0.662	5
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.643	4
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.643	5
UniProt:Q16526 CRY1	5	CRY1 [cytosol] (R-HSA-400247) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270) K48polyUb-K107,p-S-CRY1 [cytosol] (R-HSA-9932884) K48polyUb-K,p-S-CRY1 [nucleoplasm] (R-HSA-517931)	0.643	3
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.643	3
UniProt:Q5XUX0 FBXO31	1	FBXO31 [cytosol] (R-HSA-8850911)	0.643	4
IntAct:EBI-4399559 UBIQ			0.623	3
UniProt:P46527 CDKN1B	8	p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.609	2
UniProt:P61201 COPS2	2	COPS2 [nucleoplasm] (R-HSA-5697012) COPS2 [cytosol] (R-HSA-416971)	0.597	7
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.597	4
UniProt:O94952 FBXO21	1	FBXO21 [cytosol] (R-HSA-8862592)	0.597	9
UniProt:Q13098 GPS1	2	GPS1 [nucleoplasm] (R-HSA-5697010) GPS1 [cytosol] (R-HSA-416972)	0.597	6
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.597	7
UniProt:Q8TCJ0 FBX25			0.577	3
UniProt:O60826 CCDC22	2	CCDC22 [nucleoplasm] (R-HSA-8955644) CCDC22 [cytosol] (R-HSA-8955640)	0.576	3
UniProt:Q969U6 FBXW5	1	FBXW5 [cytosol] (R-HSA-391286)	0.564	3
UniProt:Q7Z6M2 FBX33			0.564	2
UniProt:Q13309-1 SKP2			0.564	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.564	2
UniProt:O94888 UBXN7	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.564	8
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) UBE2D2 [cytosol] (R-HSA-934628) UBE2D2 [nucleoplasm] (R-HSA-8852067) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153)	0.558	2
UniProt:Q83730 MT5			0.556	5
UniProt:Q8BFZ4 Fbxl21	1	Fbxl21 [cytosol] (R-MMU-9932861)	0.547	3
UniProt:Q8C4V4 Fbxl3	2	Fbxl3 [nucleoplasm] (R-MMU-508623) Fbxl3 [cytosol] (R-MMU-391289)	0.547	3
UniProt:P49427 CDC34	4	Ub-C93-CDC34 [cytosol] (R-HSA-8864170) Ub-C93-CDC34 [nucleoplasm] (R-HSA-8864204) CDC34 [nucleoplasm] (R-HSA-8852125) CDC34 [cytosol] (R-HSA-947621)	0.544	3
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.527	3
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.527	8
UniProt:Q9H4M3 FBXO44	1	FBXO44 [cytosol] (R-HSA-976031)	0.527	6
UniProt:Q9UH90 FBXO40	1	FBXO40 [cytosol] (R-HSA-8862612)	0.527	3
UniProt:Q5XUX1 FBXW9	1	FBXW9 [cytosol] (R-HSA-391290)	0.527	2
UniProt:Q6ZNC4 ZNF704	1	ZNF704 [nucleoplasm] (R-HSA-2454141)	0.527	2
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.527	2
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.527	2
UniProt:Q8IW75 SPA12			0.527	2
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.527	2
UniProt:Q5MJ09 SPXN3			0.527	2
UniProt:Q9NXK8 FBXL12	1	FBXL12 [cytosol] (R-HSA-8862611)	0.527	2
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.527	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.527	3
UniProt:P42357 HAL	1	HAL [cytosol] (R-HSA-70897)	0.527	2
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.524	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.519	7
UniProt:Q8NEZ5 FBXO22	1	FBXO22 [cytosol] (R-HSA-8862600)	0.499	4
UniProt:Q6TVW2 Q6TVW2			0.499	5
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.483	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.483	2
UniProt:Q8N3Y1 FBXW8	1	FBXW8 [cytosol] (R-HSA-976017)	0.462	2
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.462	6
UniProt:Q96ME1 FBXL18	1	FBXL18 [cytosol] (R-HSA-8854063)	0.462	6
UniProt:Q99627 COPS8	2	COPS8 [cytosol] (R-HSA-416962) COPS8 [nucleoplasm] (R-HSA-5697014)	0.462	6
UniProt:Q9H9Q2 COPS7B	2	COPS7B [nucleoplasm] (R-HSA-5697023) COPS7B [cytosol] (R-HSA-416966)	0.462	6
UniProt:Q9BT78 COPS4	2	COPS4 [nucleoplasm] (R-HSA-5697020) COPS4 [cytosol] (R-HSA-416965)	0.462	6

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