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G76-NEDD8-K859-CUL4B [nucleoplasm]
Stable Identifier
R-HSA-8952522
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-4B, CUL4B_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
NEDD8:CUL4 [nucleoplasm] (Homo sapiens)
NEDD8-CUL4B [nucleoplasm] (Homo sapiens)
G76-NEDD8-K859-CUL4B [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
NEDD8:CUL4 [nucleoplasm] (Homo sapiens)
NEDD8-CUL4B [nucleoplasm] (Homo sapiens)
G76-NEDD8-K859-CUL4B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13620 CUL4B
Gene Names
CUL4B, KIAA0695
Chain
chain:1-913
Reference Genes
BioGPS Gene:8450 CUL4B
COSMIC (genes):CUL4B CUL4B
CTD Gene:8450 CUL4B
dbSNP Gene:8450 CUL4B
ENSEMBL:ENSG00000158290 CUL4B
HGNC:2555 CUL4B
KEGG Gene (Homo sapiens):8450 CUL4B
Monarch:8450 CUL4B
NCBI Gene:8450 CUL4B
OMIM:300304 CUL4B
UCSC:Q13620 CUL4B
Reference Transcript
RefSeq:NM_001079872.1 CUL4B
RefSeq:NM_003588.3 CUL4B
RefSeq:XM_011531400.2 CUL4B
Other Identifiers
0005080047
11720094_a_at
11720095_a_at
11742846_a_at
17113744
202213_s_at
202214_s_at
210257_x_at
215997_s_at
40141_at
4019901
4019902
4019905
4019908
4019909
4019910
4019911
4019913
4019915
4019917
4019919
4019920
4019922
4019923
4019926
4019927
4019928
4019929
4019931
4019936
4019938
4019939
4019940
4019941
4019942
4019943
4019944
4019945
4019946
4019947
4019948
4019953
4019955
8174794
8450
A_23_P148463
A_23_P422178
GE53396
GE563986
GO:0000082
GO:0000278
GO:0000715
GO:0000717
GO:0003674
GO:0003677
GO:0003684
GO:0004842
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006281
GO:0006283
GO:0006293
GO:0006294
GO:0006295
GO:0006296
GO:0006464
GO:0006511
GO:0006950
GO:0006974
GO:0007049
GO:0008150
GO:0009056
GO:0010498
GO:0016567
GO:0019005
GO:0019899
GO:0022607
GO:0030154
GO:0031146
GO:0031175
GO:0031461
GO:0031465
GO:0031625
GO:0032991
GO:0033683
GO:0034641
GO:0035518
GO:0042254
GO:0042769
GO:0043161
GO:0043226
GO:0043687
GO:0045732
GO:0048856
GO:0051276
GO:0065003
GO:0070062
GO:0070911
GO:0070914
GO:0080008
GO:1900087
Hs.155976.0.S1_3p_a_at
Hs.155976.2.S1_3p_a_at
ILMN_1691535
ILMN_2385161
PH_hs_0009400
TC0X001326.hg
U58091_at
g13259126_3p_a_at
g13270466_3p_a_at
Participant Of
hasComponent
NEDD8-CUL4B [nucleoplasm]
Other forms of this molecule
CUL4B [nucleoplasm]
Inferred To
pcu4 [nucleoplasm] (Schizosaccharomyces pombe)
cul-4 [nucleoplasm] (Caenorhabditis elegans)
culE [nucleoplasm] (Dictyostelium discoideum)
Homologues of G76-NEDD8-K859-CUL4B [nucleoplasm] (Dictyostelium discoideum)
cul4b [nucleoplasm] (Danio rerio)
CUL4B [nucleoplasm] (Bos taurus)
CUL4B [nucleoplasm] (Canis familiaris)
mtss1.1 [nucleoplasm] (Xenopus tropicalis)
Cul4b [nucleoplasm] (Mus musculus)
Cul4b [nucleoplasm] (Rattus norvegicus)
culD [nucleoplasm] (Dictyostelium discoideum)
G76-NEDD8-K859-CUL4B [nucleoplasm] (Gallus gallus)
G76-NEDD8-K859-CUL4B [nucleoplasm] (Sus scrofa)
Cul4 [nucleoplasm] (Drosophila melanogaster)
Modified Residues
Name
Inter-chain Crosslink via neddylated lysine at 859 and 76
Coordinate
859
Modification
glycyl group
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
NP_001073341.1
,
NP_003579.3
,
XP_011529702.1
OpenTargets
ENSG00000158290
HPA
ENSG00000158290-CUL4B
GeneCards
Q13620
Ensembl
ENSP00000360373
,
ENSG00000158290
,
ENSP00000384109
,
ENST00000371322
,
ENST00000404115
PRO
Q13620
Orphanet
15825
PDB
4A0C
,
4A64
,
2DO7
,
4A0L
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86VP6 CAND1
5
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [nucleoplasm]
(R-HSA-8955089)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [cytosol]
(R-HSA-5691146)
0.793
13
UniProt:P62877 RBX1
2
RBX1 [cytosol]
(R-HSA-180582)
RBX1 [nucleoplasm]
(R-HSA-1234142)
0.708
5
UniProt:Q92466 DDB2
3
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
0.643
7
UniProt:Q15022 SUZ12
2
SUMO1-K75-SUZ12 [nucleoplasm]
(R-HSA-4615932)
SUZ12 [nucleoplasm]
(R-HSA-212217)
0.597
13
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.597
15
UniProt:O94888 UBXN7
1
UBXN7 [cytosol]
(R-HSA-8956071)
0.564
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:O75530 EED
1
EED [nucleoplasm]
(R-HSA-212278)
0.558
7
UniProt:Q08273
3
HRT1 [cytosol]
(R-SCE-180582)
HRT1 [cytosol]
(R-SCE-8863132)
HRT1 [nucleoplasm]
(R-SCE-1234142)
0.556
3
UniProt:P38646 HSPA9
6
HSPA9 [cytosol]
(R-HSA-5251993)
HSPA9 [nucleoplasm]
(R-HSA-5252128)
HSPA9 [mitochondrial matrix]
(R-HSA-8878802)
HSPA9(1-679) [mitochondrial intermembrane space]
(R-HSA-1267968)
HSPA9 [mitochondrial inner membrane]
(R-HSA-1252206)
HSPA9(1-679) [cytosol]
(R-HSA-1267964)
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
2
UniProt:Q15843 NEDD8
17
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
K1881-CUL9-G76-NEDD8 [cytosol]
(R-HSA-8955924)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
K705-CUL4A-G76-NEDD8 [nucleoplasm]
(R-HSA-8952528)
K859-CUL4B-G76-NEDD8 [nucleoplasm]
(R-HSA-8952538)
NEDD8(77-88) [cytosol]
(R-HSA-6782654)
NEDD8(1-88) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
K720-CUL1-G76-NEDD8 [cytosol]
(R-HSA-8952534)
K712-CUL3-G76-NEDD8 [cytosol]
(R-HSA-8952531)
K689-CUL2-G76-NEDD8 [cytosol]
(R-HSA-8952526)
K724-CUL5-G76-NEDD8 [cytosol]
(R-HSA-8952018)
NEDD8 [cytosol]
(R-HSA-416969)
K567-TGFBR2-G76-NEDD8 [cytosol]
(R-HSA-4419906)
K556-TGFBR2-G76-NEDD8 [cytosol]
(R-HSA-4419907)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
7
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