p-Y693-STAT4 dissociates after IL12:IL12R interaction

Stable Identifier
R-HSA-8952807
Type
Reaction [omitted]
Species
Homo sapiens
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Phosphorylated Signal transducer and activator of transcription 4 (STAT4) dissociates from the receptor, dimerizes, translocates to the nucleus and binds to STAT target sequences in Interleukin-12 responsive genes (Cho et al.1996, Bacon et al. 1995).
This is a Black Box Event since the exact mechanism of association and dissociation of STATs is not described.

Literature References
PubMed ID Title Journal Year
15087447 Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells

Torpey, N, Maher, SE, Bothwell, AL, Pober, JS

J. Biol. Chem. 2004
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