Reactome: A Curated Pathway Database

ADPRHL2 hydrolyses poly(ADP-ribose)

Stable Identifier
R-HSA-8952903
Type
Reaction [Depolymerisation]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Important cellular processes such as DNA repair, cellular differentiation, and carcinogenesis are regulated by poly(ADP-ribosyl)ation. Previously, only the nuclear protein poly(ADP-ribose) glycohydrolase (PARG) has been identified to hydrolyse poly(ADP-ribose). Poly(ADP-ribose) glycohydrolase ARH3 (ADPRHL2) is a mitochondrial matrix protein (Niere et al. 2008) structurally unrelated to PARG but possessing PARG activity (Oka et al. 2006). ADPRHL2 is able to hydrolyse poly(ADP-ribose) in mitochondria (Niere et al. 2012).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
poly(ADP-ribose) glycohydrolase activity of ADPRHL2 [mitochondrial matrix] ADPRHL2 [mitochondrial matrix] poly(ADP-ribose) glycohydrolase activity (0004649)
Orthologous Events