E2F7 forms homodimers

Stable Identifier
R-HSA-8952996
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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E2F7 forms homodimers (Di Stefano et al. 2003, Logan et al. 2004). While E2F7 also forms heterodimers with E2F8, co-immunoprecipitation experiments suggest that E2F7 has higher affinity for itself than for E2F8 (Li et al. 2008)

Literature References
PubMed ID Title Journal Year
18194653 Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development

Li, J, Ran, C, Li, E, Gordon, F, Comstock, G, Siddiqui, H, Cleghorn, W, Chen, HZ, Kornacker, K, Liu, CG, Pandit, SK, Khanizadeh, M, Weinstein, M, Leone, G, de Bruin, A

Dev. Cell 2008
15133492 E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains

Logan, N, Delavaine, L, Graham, A, Reilly, C, Wilson, J, Brummelkamp, TR, Hijmans, EM, Bernards, R, La Thangue, NB

Oncogene 2004
14633988 E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

Di Stefano, L, Jensen, MR, Helin, K

EMBO J. 2003
Participants
Participant Of
Orthologous Events
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