E2F8 forms homodimers

Stable Identifier
R-HSA-8953037
Type
Reaction [binding]
Species
Homo sapiens
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E2F8 forms homodimers (Maiti et al. 2005, Li et al. 2008). E2F8 also forms heterodimers with E2F7 and co-immunoprecipitation experiments suggest that E2F8 has higher affinity for E2F7 than for itself (Zalmas et al. 2008, Li et al. 2008).

Literature References
PubMed ID Title Journal Year
18202719 DNA-damage response control of E2F7 and E2F8

Zalmas, LP, Zhao, X, Graham, AL, Fisher, R, Reilly, C, Coutts, AS, La Thangue, NB

EMBO Rep. 2008
15722552 Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation

Maiti, B, Li, J, de Bruin, A, Gordon, F, Timmers, C, Opavsky, R, Patil, K, Tuttle, J, Cleghorn, W, Leone, G

J. Biol. Chem. 2005
18194653 Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development

Li, J, Ran, C, Li, E, Gordon, F, Comstock, G, Siddiqui, H, Cleghorn, W, Chen, HZ, Kornacker, K, Liu, CG, Pandit, SK, Khanizadeh, M, Weinstein, M, Leone, G, de Bruin, A

Dev. Cell 2008
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