E2F6.com-1 complex binds the E2F1 gene promoter

Stable Identifier
R-HSA-8953452
Type
Reaction [binding]
Species
Homo sapiens
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The E2F6.com-1 complex, consisting of transcription factors E2F6, TFDP1 (DP 1), MGA, MAX, histone methyltransferases EHMT1 (GLP) and EHMT2 (G9a), in complex with CBX3 (HP1gamma) and likely PRC1.6, binds to the E2F1 gene promoter. Presence of PRC1.6 components at the E2F1 gene promoter has not been tested, but is assumed based on association of PRC1.6-interacting protein CBX3 with the E2F1 promoter and the joint binding of CBX3 and PRC1.6 to the E2F6.com-1 complex (Ogawa et al. 2002). Besides the E2F1 gene promoter, the complex of E2F6.com-1 with CBX3 and possibly PRC1.6 was shown to bind to promoters of other genes involved in cell cycle progression, namely MYC, CDC25A and TK1 (Ogawa et al. 2002). However, transcriptional regulation of MYC, CDC25A and TK1 by E2F6 has not been directly demonstrated, and therefore association of E2F6 with these gene loci is not shown.

Literature References
PubMed ID Title Journal Year
12004135 A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

Ogawa, H, Ishiguro, K, Gaubatz, S, Livingston, DM, Nakatani, Y

Science 2002
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