Reactome | SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex

SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex

Stable Identifier

R-HSA-8953461

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

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SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex

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During or after processing of the transit peptide of proSMDT1 (proEMRE), the mature SMDT1 is incorporated with MCU, MCUB, MICU1, and MICU2 (or MICU3 in neurons) into the mitochondrial calcium uniporter (MCU) complex (Konig et al. 2016). MCUR1 may also be a member of the MCU complex, however this is controversial.

Literature References

PubMed ID	Title	Journal	Year
27642048	The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria Bakka, K, König, T, Rizzuto, R, Guerrero-Castillo, S, Korwitz, A, Brandt, U, Langer, T, De Stefani, D, Tröder, SE, Lampe, PA, Rugarli, EI, Decker, T, Richter-Dennerlein, R, Lauria, I, Paggio, A, Mühlmeister, M, Patron, M	Mol. Cell	2016