IMPAD1 hydrolyses PAP to AMP

Stable Identifier
R-HSA-8953499
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sulfur is an essential element in all lifeforms used in the synthesis of sulfur-containing amino acids, maintenance of cellular redox states and detoxifying toxic compounds. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) is the active form of sulfur used in these reactions, which consume PAPS, producing 3'-phosphoadenosine 5'-phosphate (PAP). PAP is degraded to 5′-AMP (AMP) by 3′-nucleotidase family. Mammals encode two 3′-nucleotidases, the Golgi-resident inositol monophosphatase 3 (IMPAD3 aka PAP phosphatase, gPAPP) and the cytosolic bisphosphate 3′-nucleotidase 1 (BPNT1, described in its own reaction). Both require Mg2+ as cofactor and both are inhibited by lithium (Hudson et al. 2013).

Literature References
PubMed ID Title Journal Year
23479625 Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis

Hudson, BH, Frederick, JP, Drake, LY, Megosh, LC, Irving, RP, York, JD

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3'(2'),5'-bisphosphate nucleotidase activity of IMPAD1:Mg2+ [Golgi lumen]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created