Reactome | PCGF6 [nucleoplasm]

PCGF6 [nucleoplasm]

Stable Identifier

R-HSA-8953572

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Polycomb group RING finger protein 6, MBLR, Mel18 and Bmi1-like RING finger, RNF134, RING finger protein 134

Locations in the PathwayBrowser for interactor UniProt:Q06587 RING1

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External Reference Information

External Reference

UniProt:Q9BYE7 PCGF6

Gene Names

PCGF6, MBLR, RNF134

Chain

chain:1-350

Reference Genes

BioGPS Gene:84108 PCGF6

COSMIC (genes):PCGF6 PCGF6

CTD Gene:84108 PCGF6

dbSNP Gene:84108 PCGF6

ENSEMBL:ENSG00000156374 PCGF6

HGNC:21156 PCGF6

KEGG:hsa:84108 PCGF6

Monarch:84108 PCGF6

NCBI Gene:84108 PCGF6

OMIM:607816 PCGF6

UCSC:Q9BYE7 PCGF6

Reference Transcript

Other Identifiers

11724980_s_at

16718022

224326_PM_s_at

224326_s_at

3304719

3304720

3304722

3304724

3304726

3304727

3304728

3304729

3304730

3304731

3304732

3304733

3304734

3304735

3304736

3304741

3826917

3826919

3826920

3826921

3826922

3826923

3826924

3826925

3826926

3826928

3826932

61670_at

7936083

8027330

84108

A_23_P115703

GE83323

GO:0000122

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0031519

GO:0035102

GO:0043226

GO:0045892

GO:0046872

HMNXSV003045773

HMNXSV003053455

ILMN_1656574

ILMN_1810181

ILMN_2401701

PH_hs_0029782

TC10001628.hg

g13537205_3p_s_at

Participates

as a component of

as an input of

E2F6 forms the PRC1L4 complex (Homo sapiens)

Inferred To

l(3)73Ah [nucleoplasm] (Drosophila melanogaster)

Pcgf6 [nucleoplasm] (Mus musculus)

Pcgf6 [nucleoplasm] (Rattus norvegicus)

mig-32 [nucleoplasm] (Caenorhabditis elegans)

PCGF6 [nucleoplasm] (Bos taurus)

PCGF6 [nucleoplasm] (Canis familiaris)

PCGF6 [nucleoplasm] (Gallus gallus)

PCGF6 [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000156374

ENSEMBL

ENST00000337211, ENST00000369847, ENSP00000338845, ENSP00000358862

HPA

ENSG00000156374-PCGF6

PRO

Q9BYE7

Pharos - Targets

Q9BYE7

PDB

2DJB

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.845	8
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.788	8
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.784	5
UniProt:O95931 CBX7			0.784	6
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.738	6
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.725	6
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.725	5
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.725	5
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.725	5
UniProt:Q8WXX7 AUTS2	1	AUTS2 [nucleoplasm] (R-HSA-8937967)	0.725	4
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.643	5
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.643	6
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.643	4
UniProt:Q8VDS3 CBX7			0.643	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	5
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.643	5
UniProt:Q14188 TFDP2	1	TFDP2 [nucleoplasm] (R-HSA-1362225)	0.643	4
UniProt:Q8IY57 YAF2	1	YAF2 [nucleoplasm] (R-HSA-8937973)	0.643	6
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.643	3
UniProt:Q8IWI9 MGA	1	MGA [nucleoplasm] (R-HSA-8953093)	0.643	4
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.643	3
UniProt:O00257 CBX4	2	monoSUMO1-K494-CBX4 [nucleoplasm] (R-HSA-4551626) CBX4 [nucleoplasm] (R-HSA-389118)	0.643	3
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.527	2
UniProt:Q5H9F3 BCORL			0.527	2
UniProt:Q8N344 MIER2			0.527	2
UniProt:Q9HAH7 FBRS			0.527	2
UniProt:Q6ICG8 WBP2L			0.527	2
UniProt:Q9Y2G2 CARD8	1	CARD8 [cytosol] (R-HSA-6805447)	0.527	2
UniProt:O00257-3 CBX4			0.499	2

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