Reactome | PHB [mitochondrial inner membrane]

PHB [mitochondrial inner membrane]

Stable Identifier

R-HSA-8953720

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Prohibitin, PHB_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P35232 PHB

Gene Names

PHB, PHB1

Chain

initiator methionine:, chain:2-272

Reference Genes

BioGPS Gene:5245 PHB

COSMIC (genes):PHB PHB

CTD Gene:5245 PHB

dbSNP Gene:5245 PHB

ENSEMBL:ENSG00000167085 PHB

ENSEMBL_homo_sapiens_GENE:ENSG00000167085.14 PHB

HGNC:8912 PHB

KEGG Gene (Homo sapiens):5245 PHB

Monarch:5245 PHB

NCBI Gene:5245 PHB

OMIM:176705 PHB

UCSC:P35232 PHB

Reference Transcript

Other Identifiers

11720609_at

11720610_x_at

11751776_a_at

16846416

200658_PM_s_at

200658_s_at

200659_PM_s_at

200659_s_at

2338404

3328113

3453061

3453064

3454751

36592_at

3660848

3761807

3761808

3761809

3761810

3761811

3761812

3761816

3761817

3761818

3761819

3761820

3761822

3761823

3761824

3761825

3761826

4016898

5245

8016552

80405_f_at

A_23_P130040

A_24_P262355

GE61229

GO:0000122

GO:0001649

GO:0001850

GO:0001851

GO:0002376

GO:0002639

GO:0003714

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005743

GO:0005768

GO:0005769

GO:0005886

GO:0006325

GO:0006351

GO:0006355

GO:0007005

GO:0007165

GO:0007202

GO:0008285

GO:0009986

GO:0010628

GO:0010944

GO:0012501

GO:0016020

GO:0019899

GO:0023035

GO:0023052

GO:0030154

GO:0030163

GO:0030308

GO:0031410

GO:0031871

GO:0032740

GO:0035632

GO:0036211

GO:0039529

GO:0040029

GO:0042113

GO:0042177

GO:0042826

GO:0042981

GO:0043226

GO:0043525

GO:0044830

GO:0045745

GO:0045892

GO:0045893

GO:0045917

GO:0046718

GO:0046982

GO:0048661

GO:0050821

GO:0050847

GO:0051897

GO:0060766

GO:0070062

GO:0070373

GO:0070374

GO:0071354

GO:0071897

GO:0072538

GO:0098542

GO:0140110

GO:0140374

GO:1901224

GO:1990051

GO:2000323

HMNXSV003057895

Hs.75323.0.A1_3p_a_at

ILMN_1692651

PH_hs_0004311

S85655_at

TC17001664.hg

g6031190_3p_a_at

Participates

as a component of

PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)

Other forms of this molecule

PHB [cytosol]

Inferred To

PHB [mitochondrial inner membrane] (Gallus gallus)

PHB [mitochondrial inner membrane] (Plasmodium falciparum)

phb1 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

phb1 [mitochondrial inner membrane] (Xenopus tropicalis)

phb-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

phbA [mitochondrial inner membrane] (Dictyostelium discoideum)

PHB1 [mitochondrial inner membrane] (Bos taurus)

PHB1 [mitochondrial inner membrane] (Canis familiaris)

PHB1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

PHB1 [mitochondrial inner membrane] (Sus scrofa)

Phb1 [mitochondrial inner membrane] (Drosophila melanogaster)

Phb1 [mitochondrial inner membrane] (Mus musculus)

Phb1 [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001268425.1, XP_016880252.1, NP_001268644.1, NP_001268426.1, NP_002625.1

OpenTargets

ENSG00000167085

GeneCards

P35232

HPA

ENSG00000167085-PHB1

Ensembl

ENST00000511832, ENSP00000425035, ENSP00000426433, ENST00000419140, ENSP00000300408, ENSP00000479488, ENSP00000484113, ENST00000504124, ENST00000512041, ENST00000300408, ENSG00000167085, ENSP00000422182, ENST00000614445, ENST00000617874, ENSP00000393320, ENST00000696365, ENSP00000512581

PRO

P35232

Pharos - Targets

P35232

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	17
UniProt:P0C6X7-PRO_0000037310 REP			0.643	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.619	6
UniProt:Q99623 PHB2	1	PHB2 [mitochondrial inner membrane] (R-HSA-8953721)	0.589	3
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9JLL3 TNR19			0.524	3
UniProt:Q496Y0 LONF3			0.524	2
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [specific granule membrane] (R-HSA-6799569)	0.508	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.463	2
UniProt:Q9NS68 TNR19			0.463	3
UniProt:P04578-PRO_0000038428 ENV			0.462	4
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2

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