Reactome | PHB2 [mitochondrial inner membrane]

PHB2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-8953721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Prohibitin-2, PHB2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99623 PHB2

Gene Names

PHB2, BAP, REA

Chain

initiator methionine:1, chain:2-299

Reference Genes

BioGPS Gene:11331 PHB2

COSMIC (genes):PHB2 PHB2

CTD Gene:11331 PHB2

dbSNP Gene:11331 PHB2

ENSEMBL:ENSG00000215021 PHB2

HGNC:30306 PHB2

KEGG Gene (Homo sapiens):11331 PHB2

Monarch:11331 PHB2

NCBI Gene:11331 PHB2

OMIM:610704 PHB2

UCSC:Q99623 PHB2

Reference Transcript

Other Identifiers

0004210520

11331

11715383_a_at

11715384_x_at

11753313_a_at

16760649

201600_at

3442397

3442402

3442405

3442412

3442414

3442415

3442418

3442421

3442423

3442424

37364_at

7960716

A_23_P151106

A_33_P3368328

GE54942

GO:0000003

GO:0000278

GO:0000423

GO:0002376

GO:0002377

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005741

GO:0005743

GO:0005886

GO:0006091

GO:0006464

GO:0006606

GO:0006629

GO:0006810

GO:0006851

GO:0006913

GO:0006914

GO:0006950

GO:0007005

GO:0007049

GO:0007059

GO:0007062

GO:0007165

GO:0007202

GO:0008022

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008289

GO:0009056

GO:0009058

GO:0009611

GO:0009986

GO:0014069

GO:0015031

GO:0016020

GO:0016363

GO:0016477

GO:0023035

GO:0030331

GO:0030424

GO:0031536

GO:0032991

GO:0033147

GO:0033218

GO:0033600

GO:0034641

GO:0035632

GO:0039520

GO:0039529

GO:0040011

GO:0042113

GO:0042802

GO:0042803

GO:0043066

GO:0043226

GO:0043433

GO:0044403

GO:0045892

GO:0046625

GO:0046982

GO:0047485

GO:0048786

GO:0048856

GO:0048870

GO:0050821

GO:0051091

GO:0051276

GO:0055085

GO:0060744

GO:0060749

GO:0060762

GO:0070374

GO:0071300

GO:0071456

GO:0071944

GO:0098800

GO:0098978

GO:0098982

GO:0140014

GO:0140374

GO:1900208

GO:1901224

GO:1902808

GO:1904959

GO:1990051

ILMN_1696087

PH_hs_0025971

TC12001153.hg

U72511_at

g6005853_3p_at

Participant Of

hasComponent

PHB:PHB2 [mitochondrial inner membrane]

Inferred To

phb2a [mitochondrial inner membrane] (Danio rerio)

phb2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

phb2 [mitochondrial inner membrane] (Xenopus tropicalis)

phb-2 [mitochondrial inner membrane] (Caenorhabditis elegans)

phbB [mitochondrial inner membrane] (Dictyostelium discoideum)

PHB2 [mitochondrial inner membrane] (Canis familiaris)

PHB2 [mitochondrial inner membrane] (Gallus gallus)

PHB2 [mitochondrial inner membrane] (Plasmodium falciparum)

PHB2 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

PHB2 [mitochondrial inner membrane] (Sus scrofa)

Phb2 [mitochondrial inner membrane] (Drosophila melanogaster)

Phb2 [mitochondrial inner membrane] (Mus musculus)

Phb2 [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001138303.1, NP_001254629.1

OpenTargets

ENSG00000215021

HPA

ENSG00000215021-PHB2

GeneCards

Q99623

Ensembl

ENST00000440277, ENSG00000215021, ENSP00000441875, ENSP00000412856, ENST00000535923

PRO

Q99623

PDB

6IQE

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35232 PHB	2	PHB [mitochondrial inner membrane] (R-HSA-8953720) PHB [cytosol] (R-HSA-5672944)	0.589	3
sphingosine 1-phosphate [ChEBI:37550]	3	S1P [plasma membrane] (R-ALL-5218688) S1P [cytosol] (R-ALL-428203) S1P [extracellular region] (R-ALL-419305)	0.524	9
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.508	4