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PHB2 [mitochondrial inner membrane]
Stable Identifier
R-HSA-8953721
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Prohibitin-2, PHB2_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Mitochondrial calcium ion transport (Homo sapiens)
Processing of SMDT1 (Homo sapiens)
AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99623 PHB2
Gene Names
PHB2, BAP, REA
Chain
initiator methionine:1, chain:2-299
Reference Genes
BioGPS Gene:11331 PHB2
COSMIC (genes):PHB2 PHB2
CTD Gene:11331 PHB2
dbSNP Gene:11331 PHB2
ENSEMBL:ENSG00000215021 PHB2
HGNC:30306 PHB2
KEGG Gene (Homo sapiens):11331 PHB2
Monarch:11331 PHB2
NCBI Gene:11331 PHB2
OMIM:610704 PHB2
UCSC:Q99623 PHB2
Reference Transcript
RefSeq:NM_001267700.1 PHB2
RefSeq:NM_001144831.1 PHB2
Other Identifiers
0004210520
11331
11715383_a_at
11715384_x_at
11753313_a_at
16760649
201600_at
3442397
3442402
3442405
3442412
3442414
3442415
3442418
3442421
3442423
3442424
37364_at
7960716
A_23_P151106
A_33_P3368328
GE54942
GO:0000003
GO:0000278
GO:0000423
GO:0002376
GO:0002377
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005741
GO:0005743
GO:0005886
GO:0006091
GO:0006464
GO:0006606
GO:0006629
GO:0006810
GO:0006851
GO:0006913
GO:0006914
GO:0006950
GO:0007005
GO:0007049
GO:0007059
GO:0007062
GO:0007165
GO:0007202
GO:0008022
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008289
GO:0009056
GO:0009058
GO:0009611
GO:0009986
GO:0014069
GO:0015031
GO:0016020
GO:0016363
GO:0016477
GO:0023035
GO:0030331
GO:0030424
GO:0031536
GO:0032991
GO:0033147
GO:0033218
GO:0033600
GO:0034641
GO:0035632
GO:0039520
GO:0039529
GO:0040011
GO:0042113
GO:0042802
GO:0042803
GO:0043066
GO:0043226
GO:0043433
GO:0044403
GO:0045892
GO:0046625
GO:0046982
GO:0047485
GO:0048786
GO:0048856
GO:0048870
GO:0050821
GO:0051091
GO:0051276
GO:0055085
GO:0060744
GO:0060749
GO:0060762
GO:0070374
GO:0071300
GO:0071456
GO:0071944
GO:0098800
GO:0098978
GO:0098982
GO:0140014
GO:0140374
GO:1900208
GO:1901224
GO:1902808
GO:1904959
GO:1990051
ILMN_1696087
PH_hs_0025971
TC12001153.hg
U72511_at
g6005853_3p_at
Participant Of
hasComponent
PHB:PHB2 [mitochondrial inner membrane]
Inferred To
phb2a [mitochondrial inner membrane] (Danio rerio)
phb2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)
phb2 [mitochondrial inner membrane] (Xenopus tropicalis)
phb-2 [mitochondrial inner membrane] (Caenorhabditis elegans)
phbB [mitochondrial inner membrane] (Dictyostelium discoideum)
PHB2 [mitochondrial inner membrane] (Canis familiaris)
PHB2 [mitochondrial inner membrane] (Gallus gallus)
PHB2 [mitochondrial inner membrane] (Plasmodium falciparum)
PHB2 [mitochondrial inner membrane] (Saccharomyces cerevisiae)
PHB2 [mitochondrial inner membrane] (Sus scrofa)
Phb2 [mitochondrial inner membrane] (Drosophila melanogaster)
Phb2 [mitochondrial inner membrane] (Mus musculus)
Phb2 [mitochondrial inner membrane] (Rattus norvegicus)
Cross References
RefSeq
NP_001138303.1
,
NP_001254629.1
OpenTargets
ENSG00000215021
HPA
ENSG00000215021-PHB2
GeneCards
Q99623
Ensembl
ENST00000440277
,
ENSG00000215021
,
ENSP00000441875
,
ENSP00000412856
,
ENST00000535923
PRO
Q99623
PDB
6IQE
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35232 PHB
2
PHB [mitochondrial inner membrane]
(R-HSA-8953720)
PHB [cytosol]
(R-HSA-5672944)
0.589
3
sphingosine 1-phosphate [ChEBI:37550]
3
S1P [plasma membrane]
(R-ALL-5218688)
S1P [cytosol]
(R-ALL-428203)
S1P [extracellular region]
(R-ALL-419305)
0.524
9
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.508
4
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