Reactome: A Curated Pathway Database

Metabolism of RNA

Stable Identifier
R-HSA-8953854
Type
TopLevelPathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

This superpathway encompasses the processes by which RNA transcription products are further modified covalently and non-covalently to yield their mature forms, and the regulation of these processes. Annotated pathways include ones for capping, splicing, and 3'-cleavage and polyadenylation to yield mature mRNA molecules that are exported from the nucleus (Hocine et al. 2010). mRNA editing and nonsense-mediated decay are also annotated. Processes leading to mRNA breakdown are described: deadenylation-dependent mRNA decay, microRNA-mediated RNA cleavage, and regulation of mRNA stability by proteins that bind AU-rich elements.psnRNP assembly is also annotated here.

The aminoacylation of mature tRNAs is annotated in the "Metabolism of proteins" superpathway, as a part of "Translation".

Literature References
PubMed ID Title Journal Year
20961978 RNA processing and export Cold Spring Harb Perspect Biol 2010
Participants
Orthologous Events