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PEX12 [peroxisomal membrane]
Stable Identifier
R-HSA-8953911
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
peroxisomal membrane
Synonyms
Peroxisome assembly protein 12, PEX12_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Class I peroxisomal membrane protein import (Homo sapiens)
PEX3:PEX19:class I PMP dissociates (Homo sapiens)
Class I Peroxisomal Membrane Proteins [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5L:PEX7:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX12 [peroxisomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00623 PEX12
Gene Names
PEX12, PAF3
Chain
chain:1-359
Reference Genes
BioGPS Gene:5193 PEX12
COSMIC (genes):PEX12 PEX12
CTD Gene:5193 PEX12
dbSNP Gene:5193 PEX12
ENSEMBL:ENSG00000108733 PEX12
HGNC:8854 PEX12
KEGG Gene (Homo sapiens):5193 PEX12
Monarch:5193 PEX12
NCBI Gene:5193 PEX12
OMIM:601758 PEX12
UCSC:O00623 PEX12
Reference Transcript
RefSeq:NM_000286.2 PEX12
Other Identifiers
0001090717
11722830_at
16843462
205094_PM_at
205094_at
35157_at
3753691
3753692
3753693
3753694
3753695
3753696
3753697
3753698
3753699
3753700
3753701
3753702
3753704
5193
8014264
A_24_P416411
GE59561
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005777
GO:0005778
GO:0005779
GO:0005829
GO:0006464
GO:0006513
GO:0006605
GO:0006625
GO:0006810
GO:0007031
GO:0008022
GO:0008150
GO:0008270
GO:0015031
GO:0016020
GO:0016021
GO:0016558
GO:0032991
GO:0043167
GO:0043226
GO:0046872
GO:0055085
GO:1990429
HMNXSV003044965
ILMN_1664448
PH_hs_0002280
TC17001374.hg
U91521_at
g4505720_3p_at
Participates
as a member of
Class I Peroxisomal Membrane Proteins [peroxisomal membrane] (Homo sapiens)
as a component of
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
Other forms of this molecule
PEX12 [cytosol]
Inferred To
PEX12 [peroxisomal membrane]
(Bos taurus)
PEX12 [peroxisomal membrane]
(Canis familiaris)
PEX12 [peroxisomal membrane]
(Gallus gallus)
PEX12 [peroxisomal membrane]
(Saccharomyces cerevisiae)
PEX12 [peroxisomal membrane]
(Sus scrofa)
Pex12 [peroxisomal membrane]
(Drosophila melanogaster)
Pex12 [peroxisomal membrane]
(Mus musculus)
Pex12 [peroxisomal membrane]
(Rattus norvegicus)
pex12 [peroxisomal membrane]
(Danio rerio)
pex12 [peroxisomal membrane]
(Dictyostelium discoideum)
pex12 [peroxisomal membrane]
(Schizosaccharomyces pombe)
pex12 [peroxisomal membrane]
(Xenopus tropicalis)
prx-12 [peroxisomal membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000277.1
OpenTargets
ENSG00000108733
GeneCards
O00623
HPA
ENSG00000108733-PEX12
Ensembl
ENST00000225873
,
ENSG00000108733
,
ENSP00000225873
PRO
O00623
Pharos - Targets
O00623
Orphanet
16639
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50542 PEX5
4
p-PEX5 [peroxisomal membrane]
(R-HSA-9665182)
Ub-p-PEX5 [peroxisomal membrane]
(R-HSA-9665183)
PEX5 [peroxisomal membrane]
(R-HSA-9665164)
PEX5 [cytosol]
(R-HSA-9033132)
0.683
4
UniProt:Q15848 ADIPOQ
1
ADIPOQ [extracellular region]
(R-HSA-1183052)
0.556
3
UniProt:Q7L5A8 FA2H
1
FA2H [endoplasmic reticulum membrane]
(R-HSA-5693771)
0.556
3
UniProt:P17152 TMEM11
1
TMEM11 [mitochondrial inner membrane]
(R-HSA-8949578)
0.556
3
UniProt:P29033 GJB2
3
GJB2 [endoplasmic reticulum-Golgi intermediate compartment]
(R-HSA-190614)
GJB2 [endoplasmic reticulum membrane]
(R-HSA-1629779)
GJB2 [plasma membrane]
(R-HSA-53211)
0.556
3
UniProt:P49638 TTPA
1
TTPA [cytosol]
(R-HSA-2980979)
0.556
3
UniProt:Q8WVV5 BTN2A2
1
BTN2A2 [plasma membrane]
(R-HSA-8851047)
0.556
3
UniProt:Q12982 BNIP2
1
BNIP2 [cytosol]
(R-HSA-200792)
0.556
3
UniProt:P40855 PEX19
1
PEX19 [cytosol]
(R-HSA-3009036)
0.527
2
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