PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3

Stable Identifier
R-HSA-8953917
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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A RING E3 ubiquitin ligase complex containing PEX10, PEX12, and PEX2 ubiquitinates PEX5L. The PEX2:PEX10:PEX12 complex is believed to bind an activated E2-ubiquitin conjugate (one of Ub:UBE2D1, Ub:UBE2D2, Ub:UBE2D3) and PEX5L in a complex that also contains PEX13 and PEX14 (Chang et al. 1999, Carvalho et al. 2007, Grou et al. 2008, Grou et al. 2009, Okumoto et al. 2011). The short isoform of PEX5, PEX5S, is inferred to undergo the same reaction.

Literature References
PubMed ID Title Journal Year
18359941 Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor

Grou, CP, Carvalho, AF, Pinto, MP, Wiese, S, Piechura, H, Meyer, HE, Warscheid, B, Sá-Miranda, C, Azevedo, JE

J. Biol. Chem. 2008
10562279 PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import

Chang, CC, Warren, DS, Sacksteder, KA, Gould, SJ

J. Cell Biol. 1999
19208625 Properties of the ubiquitin-pex5p thiol ester conjugate

Grou, CP, Carvalho, AF, Pinto, MP, Huybrechts, SJ, Sá-Miranda, C, Fransen, M, Azevedo, JE

J. Biol. Chem. 2009
21554508 Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling

Okumoto, K, Misono, S, Miyata, N, Matsumoto, Y, Mukai, S, Fujiki, Y

Traffic 2011
17726030 Ubiquitination of mammalian Pex5p, the peroxisomal import receptor

Carvalho, AF, Pinto, MP, Grou, CP, Alencastre, IS, Fransen, M, Sá-Miranda, C, Azevedo, JE

J. Biol. Chem. 2007
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