E2F6:TFDP1:EPC1 binds the PRC2 complex

Stable Identifier
R-HSA-8954110
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In late G1 and in S phase of the cell cycle, the complex of E2F6, TFDP1 and EPC1 interacts with EZH2, a component of the Polycomb group complex PRC2. EZH2 directly binds to E2F6. EED, another component of the PRC2 complex, co-immunoprecipitates with EZH2 and co-elutes with the E2F6-containing cell fraction. Co-immunoprecipitation of other components of the PRC2 complex with E2F6 has not been examined. It is suggested that the complex of E2F6 and PRC2 regulates expression of genes needed for cell cycle progression (Attwooll et al. 2005).

Literature References
PubMed ID Title Journal Year
15536069 A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner

Attwooll, C, Oddi, S, Cartwright, P, Prosperini, E, Agger, K, Steensgaard, P, Wagener, C, Sardet, C, Moroni, MC, Helin, K

J. Biol. Chem. 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created