Reactome | E2F6:TFDP1 binds EPC1

E2F6:TFDP1 binds EPC1

Stable Identifier

R-HSA-8954117

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The heterodimer of E2F6 and TFDP1 (DP-1) forms a stable tripartite complex with EPC1. EPC1 is a component of the NuA4 histone acetyltransferase complex. The complex of E2F6 and EPC1 acts as a repressive complex in a CAT reporter assay, but the presence of other NuA4 components has not been detected in co-immunoprecipitates of E2F6 and EPC1. EPC1 directly interacts with E2F6 but not with TFDP1 (Attwooll et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15536069	A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner Helin, K, Oddi, S, Moroni, MC, Prosperini, E, Attwooll, C, Agger, K, Steensgaard, P, Cartwright, P, Sardet, C, Wagener, C	J. Biol. Chem.	2005