E2F6:TFDP1 binds EPC1

Stable Identifier
R-HSA-8954117
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The heterodimer of E2F6 and TFDP1 (DP-1) forms a stable tripartite complex with EPC1. EPC1 is a component of the NuA4 histone acetyltransferase complex. The complex of E2F6 and EPC1 acts as a repressive complex in a CAT reporter assay, but the presence of other NuA4 components has not been detected in co-immunoprecipitates of E2F6 and EPC1. EPC1 directly interacts with E2F6 but not with TFDP1 (Attwooll et al. 2005).

Literature References
PubMed ID Title Journal Year
15536069 A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner

Attwooll, C, Oddi, S, Cartwright, P, Prosperini, E, Agger, K, Steensgaard, P, Wagener, C, Sardet, C, Moroni, MC, Helin, K

J. Biol. Chem. 2005
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