UCKL1 phosphorylates urindine, cytidine

Stable Identifier
R-HSA-8954327
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Based on sequence similarity, cytosolic uridine-cytidine kinase-like 1 (UCKL1 aka F538) is thought to function as a novel human uridine kinase/uracil phosphoribosyltransferase (Kashuba et al. 2002). The two human uridine kinases 1 and 2 (UCK1 and UCK2) characterised to date phosphorylate uridine/cytidine to uridine monophosphate (UMP)/cytidine monophosphate (CMP) using ATP as a phosphate donor (Greenberg et al. 1977, Van Rompay et al. 2001).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
uridine kinase activity of UCKL1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Cross References
Rhea