Reactome: A Curated Pathway Database

UCKL1 phosphorylates urindine, cytidine

Stable Identifier
R-HSA-8954327
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Based on sequence similarity, cytosolic uridine-cytidine kinase-like 1 (UCKL1 aka F538) is thought to function as a novel human uridine kinase/uracil phosphoribosyltransferase (Kashuba et al. 2002). The two human uridine kinases 1 and 2 (UCK1 and UCK2) characterised to date phosphorylate uridine/cytidine to uridine monophosphate (UMP)/cytidine monophosphate (CMP) using ATP as a phosphate donor (Greenberg et al. 1977, Van Rompay et al. 2001).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
uridine kinase activity of UCKL1 [cytosol] UCKL1 [cytosol] uridine kinase activity (0004849)
Orthologous Events