UCKL1 phosphorylates urindine, cytidine

Stable Identifier
R-HSA-8954327
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Based on sequence similarity, cytosolic uridine-cytidine kinase-like 1 (UCKL1 aka F538) is thought to function as a novel human uridine kinase/uracil phosphoribosyltransferase (Kashuba et al. 2002). The two human uridine kinases 1 and 2 (UCK1 and UCK2) characterised to date phosphorylate uridine/cytidine to uridine monophosphate (UMP)/cytidine monophosphate (CMP) using ATP as a phosphate donor (Greenberg et al. 1977, Van Rompay et al. 2001).

Literature References
PubMed ID Title Journal Year
12199906 Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase

Kashuba, E, Kashuba, V, Sandalova, T, Klein, G, Székely, L

BMC Cell Biol. 2002
195585 Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma

Greenberg, N, Schumm, DE, Webb, TE

Biochem J 1977
11306702 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases

Van Rompay, AR, Norda, A, Linden, K, Johansson, M, Karlsson, A

Mol Pharmacol 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
uridine kinase activity of UCKL1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created