NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA

Stable Identifier
R-HSA-8954468
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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N-acetylaspartate (NAA) is a highly abundant brain metabolite which delivers the acetate moiety for synthesis of acetyl-CoA, further utilised for fatty acid generation. In the mitochondrial matrix of neuronal cells, N-acetylaspartate synthetase (NAT8L) catalyses the formation of NAA from acetyl-CoA (Ac-CoA) and L-aspartatic acid (L-Asp) (Wiame et al. 2009, Pessentheiner et al. 2013, Prokesch et al. 2016).

Literature References
PubMed ID Title Journal Year
27045997 N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes

Prokesch, A, Pelzmann, HJ, Pessentheiner, AR, Huber, K, Madreiter-Sokolowski, CT, Drougard, A, Schittmayer, M, Kolb, D, Magnes, C, Trausinger, G, Graier, WF, Birner-Gruenberger, R, Pospisilik, JA, Bogner-Strauss, JG

Sci Rep 2016
24155240 NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes

Pessentheiner, AR, Pelzmann, HJ, Walenta, E, Schweiger, M, Groschner, LN, Graier, WF, Kolb, D, Uno, K, Miyazaki, T, Nitta, A, Rieder, D, Prokesch, A, Bogner-Strauss, JG

J. Biol. Chem. 2013
19807691 Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia

Wiame, E, Tyteca, D, Pierrot, N, Collard, F, Amyere, M, Noel, G, Desmedt, J, Nassogne, MC, Vikkula, M, Octave, JN, Vincent, MF, Courtoy, PJ, Boltshauser, E, Van Schaftingen, E

Biochem. J. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aspartate N-acetyltransferase activity of NAT8L [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created