Reactome | COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes

COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes

Stable Identifier

R-HSA-8955289

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes

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COMMD1 is a member of a family of 10 copper metabolism MURR1 domain-containing proteins that have pleiotropic roles in copper metabolism, NF kappa beta-mediated transcription, the hypoxic response and electrolyte transport (Burstein et al, 2005; reviewed in Maine and Burstein, 2007). COMMD proteins have differential tissue and expression levels, but appear to have partially overlapping function and form homo- and heterodimers through the shared COMM domain (Burstein et al, 2005). COMMD1 and other family members interact with the cullin subunit of CRL E3 ubiquitin ligase complexes, as well as with CCDC22, a protein implicated in X-linked intellectual disability that may regulate COMMD localization. Together, COMMD proteins and CCDC22 activate the ubiquitin ligase activity of CRL complexes by displacing the CAND1 inhibitor (Burstein et al, 2005; Maine et al, 2007; Mao et al, 2011; Starokadomskyy et al, 2013;Phillips-Krawczak et al, 2015). The specificity of interaction between various COMMD and CUL family members may serve to fine tune the regulation of CRL activation, although these details remain to be determined.

Literature References

PubMed ID	Title	Journal	Year
17183367	COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase Maine, GN, Mao, X, Komarck, CM, Burstein, E	EMBO J.	2007
21778237	COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding Gluck, N, Maine, GN, Li, H, Starokadomskyy, P, Chen, B, Mao, X, Burstein, E	J. Biol. Chem.	2011
23563313	CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling Gluck, N, Zecha, A, Maine, GN, Li, H, Wallis, M, Ropers, HH, Starokadomskyy, P, Hein, MY, McDonald, FJ, Zaidi, IW, McGaughran, J, Kuss, AW, Lenzner, S, Mao, X, Chen, B, Gecz, J, Burstein, E	J. Clin. Invest.	2013
17497243	COMMD proteins: COMMing to the scene Maine, GN, Burstein, E	Cell. Mol. Life Sci.	2007
15799966	COMMD proteins, a novel family of structural and functional homologs of MURR1 Hoberg, JE, Maine, GN, Duckett, CS, Wilkinson, AS, Wilkinson, JC, Rumble, JM, Csomos, RA, Mayo, MW, Komarck, CM, Burstein, E	J. Biol. Chem.	2005
25355947	COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A Gomez, TS, Dai, H, Kaufmann, SH, Billadeau, DD, Zhang, JS, Sluis, Bv, Li, H, Geng, LN, Wallis, M, Dick, CJ, Deng, Z, Starokadomskyy, P, Hein, MY, McGaughran, J, Koenecke, M, Osborne, DG, Phillips-Krawczak, CA, Gecz, J, Singla, A, Burstein, E, Sifuentes-Dominguez, LF	Mol. Biol. Cell	2015