Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TUBA1A(1-450) [cytosol]
Stable Identifier
R-HSA-8955577
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
alpha tubulin 3(1-450), delY451-TUBA1A
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer (Homo sapiens)
detyr-alpha tubulin:beta tubulin [cytosol] (Homo sapiens)
detyr-alpha-tubulin:GTP [cytosol] (Homo sapiens)
detyr-alpha-tubulin [cytosol] (Homo sapiens)
TUBA1A(1-450) [cytosol] (Homo sapiens)
TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin (Homo sapiens)
detyr-alpha tubulin:beta tubulin [cytosol] (Homo sapiens)
detyr-alpha-tubulin:GTP [cytosol] (Homo sapiens)
detyr-alpha-tubulin [cytosol] (Homo sapiens)
TUBA1A(1-450) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q71U36 TUBA1A
Gene Names
TUBA1A, TUBA3
Chain
chain:1-451, chain:1-450
Reference Genes
BioGPS Gene:7846 TUBA1A
COSMIC (genes):TUBA1A TUBA1A
CTD Gene:7846 TUBA1A
dbSNP Gene:7846 TUBA1A
ENSEMBL:ENSG00000167552 TUBA1A
ENSEMBL_homo_sapiens_GENE:ENSG00000167552.15 TUBA1A
HGNC:20766 TUBA1A
KEGG Gene (Homo sapiens):7846 TUBA1A
Monarch:7846 TUBA1A
NCBI Gene:7846 TUBA1A
OMIM:602529 TUBA1A
UCSC:Q71U36 TUBA1A
Reference Transcript
RefSeq:NM_006009.3 TUBA1A
RefSeq:NM_001270399.1 TUBA1A
RefSeq:NM_001270400.1 TUBA1A
Other Identifiers
11727362_x_at
11757913_x_at
201090_x_at
209118_PM_s_at
209118_s_at
209251_PM_x_at
211058_x_at
211750_PM_x_at
212639_PM_x_at
212639_x_at
213646_PM_x_at
213646_x_at
2872626
3344241
3413815
3413819
3413822
3453739
3453741
3453742
3453746
3453748
3453749
3453838
3453839
3453840
3453841
3453842
3453844
3453845
3453846
3453849
3453850
3453851
3453852
3453853
3453855
3453856
3453857
3453858
3453859
3453860
3640627
40567_at
59760_f_at
7846
7963054
A_23_P139547
GE541560
GO:0000166
GO:0000226
GO:0000278
GO:0000793
GO:0001764
GO:0001964
GO:0003824
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0005737
GO:0005768
GO:0005829
GO:0005856
GO:0005874
GO:0005879
GO:0005881
GO:0005886
GO:0005929
GO:0006886
GO:0007010
GO:0007017
GO:0007018
GO:0007098
GO:0007224
GO:0007613
GO:0007626
GO:0008344
GO:0008542
GO:0009612
GO:0010001
GO:0010467
GO:0012501
GO:0015630
GO:0016787
GO:0021542
GO:0021696
GO:0021766
GO:0021859
GO:0021987
GO:0022008
GO:0023052
GO:0030154
GO:0030182
GO:0030534
GO:0030705
GO:0031410
GO:0031594
GO:0034330
GO:0034612
GO:0035641
GO:0036464
GO:0042802
GO:0043226
GO:0044877
GO:0045202
GO:0046785
GO:0046872
GO:0046982
GO:0048853
GO:0048856
GO:0048870
GO:0048873
GO:0050807
GO:0050808
GO:0050877
GO:0051301
GO:0051402
GO:0055037
GO:0061744
GO:0065003
GO:0070062
GO:0071277
GO:0072384
GO:0140058
GO:1902065
HMNXSV003015261
ILMN_1742981
ILMN_2148819
TC12000363.hg
TC12001472.hg
TC12002866.hg
X01703_at
g4929133_3p_s_at
Participates
as a candidate of
detyr-alpha-tubulin [cytosol] (Homo sapiens)
Other forms of this molecule
AcK-TUBA1A [cytosol]
Ac K40 TUBA1A [axonemal microtubule]
TUBA1A folding intermediate [cytosol]
TUBA1A unfolded [cytosol]
L-isoglutamyl polyglycyl-TUBA1A [cytosol]
Polyglutamyl-TUBA1A [cytosol]
TUBA1A [cytosol]
TUBA1A [axonemal microtubule]
Cross References
RefSeq
NP_001257328.1
,
NP_006000.2
,
NP_001257329.1
Guide to Pharmacology - Targets
2638
OpenTargets
ENSG00000167552
HPA
ENSG00000167552-TUBA1A
GeneCards
Q71U36
Ensembl
ENST00000550767
,
ENST00000547939
,
ENSP00000446637
,
ENSP00000450268
,
ENST00000301071
,
ENSP00000439020
,
ENSP00000448725
,
ENST00000552924
,
ENSP00000301071
,
ENSG00000167552
,
ENST00000295766
PRO
Q71U36
Pharos - Targets
Q71U36
Orphanet
17324
PDB
8J07
,
6WSL
,
7UN1
,
7C1M
,
6J8F
,
7UNG
,
5JCO
HMDB Protein
HMDBP08593
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.745
4
UniProt:Q9UBS4 DNAJB11
1
DNAJB11 [endoplasmic reticulum lumen]
(R-HSA-381040)
0.725
4
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.687
7
UniProt:P31689 DNAJA1
2
SOH-C149,C150-DNAJA1 [cytosol]
(R-HSA-9857072)
DNAJA1 [cytosol]
(R-HSA-3371544)
0.671
6
UniProt:Q8N0Z6 TTC5
3
TTC5 [nucleoplasm]
(R-HSA-6804264)
p-S203-TTC5 [nucleoplasm]
(R-HSA-6804261)
p-S203,S221-TTC5 [nucleoplasm]
(R-HSA-6804259)
0.615
3
UniProt:Q9NQC7 CYLD
3
K48polyUb-K338, K530-CYLD [cytosol]
(R-HSA-9818664)
p-S418-CYLD [cytosol]
(R-HSA-5212667)
CYLD [cytosol]
(R-HSA-741420)
0.576
6
UniProt:Q9UBX3 SLC25A10
1
SLC25A10 [mitochondrial inner membrane]
(R-HSA-372848)
0.569
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
4
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.564
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.547
5
UniProt:Q9UBN7 HDAC6
4
HDAC6 [nucleoplasm]
(R-HSA-351589)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
0.534
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
2
UniProt:Q9Y337 KLK5
4
KLK5 [extracellular region]
(R-HSA-8849629)
proKLK5 [extracellular region]
(R-HSA-8849836)
KLK5 propeptide [extracellular region]
(R-HSA-8849839)
KLK5 [cytosol]
(R-HSA-8934778)
0.527
3
UniProt:P42677 RPS27
2
RPS27 [nucleoplasm]
(R-HSA-6791190)
RPS27 [cytosol]
(R-HSA-72361)
0.527
2
UniProt:A6NED2 RCCD1
2
3OHR141-RCCD1 [cytosol]
(R-HSA-9629871)
RCCD1 [cytosol]
(R-HSA-9629873)
0.527
2
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
4
UniProt:Q07954 LRP1
2
LRP1 [plasma membrane]
(R-HSA-1454844)
LRP1 [endocytic vesicle membrane]
(R-HSA-2230981)
0.527
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
3
UniProt:Q9HC77 CENPJ
2
CENPJ [cytosol]
(R-HSA-380291)
p-S589,S595-CENPJ [cytosol]
(R-HSA-6801670)
0.483
2
UniProt:Q9H0U3 MAGT1
2
MAGT1 [azurophil granule membrane]
(R-HSA-6799208)
MAGT1 [plasma membrane]
(R-HSA-4836523)
0.483
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text