SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer

Stable Identifier
R-HSA-8955712
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer
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TTCP (tubulinyl-tyrosine carboxypeptidase) hydrolyzes the terminal L-Tyr residue from the alpha-tubulin subunit of an alpha tubulin:beta tubulin dimer to yield delY-alpha tubulin and L-tyrosine (L-Tyr). Although TTCP enzyme has not been purified from any species, studies of material partially purified from chicken brain have allowed its activity to be defined and distinguished from those of widely expressed carboxypeptidases with broader substrate specificities (Argarana et al. 1980). This reaction is known to occur in humans (Song & Brody 2015; Yu et al. 2015) and its properties have been inferred from those of its chicken counterpart.
Literature References
PubMed ID Title Journal Year
25957412 Writing and Reading the Tubulin Code

Roll-Mecak, A, Yu, I, Garnham, CP

J. Biol. Chem. 2015
25468068 Post-translational modifications of tubulin: pathways to functional diversity of microtubules

Brady, ST, Song, Y

Trends Cell Biol. 2015
7452228 Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification

Caputto, R, Barra, HS, Argarana, CE

J. Neurochem. 1980
29146868 Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

Sanman, LE, Delphin, C, Lafanechère, L, Aillaud, C, Syed, S, Amara, N, Boulan, B, Bosson, A, Rogowski, K, van Dijk, J, Pelletier, L, Denarier, E, Couté, Y, Bosc, C, Le Friec, J, Heemeryck, P, Humbert, S, Vossier, F, Bogyo, M, Moutin, MJ, Andrieux, A, Peris, L

Science 2017
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Output
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Event Information
Go Biological Process
C-terminal protein amino acid modification (0018410)
Catalyst Activity

metallocarboxypeptidase activity of SVBP:VASH1,VASH2 [cytosol]

Physical Entity
SVBP:VASH1,VASH2 [cytosol] (Homo sapiens)
Activity
metallocarboxypeptidase activity (GO:0004181)
Inferred From
TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin (Bos taurus)
Authored
D'Eustachio, P  (2017-01-13)
Reviewed
Jassal, B  (2017-01-19)
Created
D'Eustachio, P  (2017-01-13)
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