PGM2L1:Mg2+ phosphorylates G6P to G1,6BP

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R-HSA-8955760
Type
Reaction
Species
Homo sapiens
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Summation

1,3-bisphosphoglycerate (1,3BPG) is the first energy rich intermediate of glycolysis. Cytosolic glucose 1,6-bisphosphate synthase (PGM2L1) utilises 1,3BPG as a phosphate donor to phosphorylate a series of 1-phosphate sugars. Although 5- and 6-phosphate sugars are poor substrates for PGM2L1, glucose 6-phosphate (G6P) is the exception (Maliekal et al. 2007, Veiga-da-Cunha et al. 2008). PGM2L1 complexed with Mg2+ as cofactor, phosphorylates G6P to glucose 1,6-bisphosphate (G1,6BP), a cofactor for phosphomutases and a putative regulator of glycolysis. PGM2L1 is mainly expressed in brain where its activity is particularly high (Maliekal et al. 2007).

Literature References
PubMed ID Title Journal Year
17804405 Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family

Maliekal, P, Sokolova, T, Vertommen, D, Veiga-da-Cunha, M, Van Schaftingen, E

J Biol Chem 2007
18927083 Mammalian phosphomannomutase PMM1 is the brain IMP-sensitive glucose-1,6-bisphosphatase

Veiga-da-Cunha, M, Vleugels, W, Maliekal, P, Matthijs, G, Van Schaftingen, E

J. Biol. Chem. 2008
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Catalyst Activity
Catalyst Activity
Title
glucose-1,6-bisphosphate synthase activity of PGM2L1:Mg2+ [cytosol]
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