Reactome: A Curated Pathway Database

PGP:Mg2+ dimer hydrolyses 3PG to glycerol

Stable Identifier
R-HSA-8955794
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Glycerol-3-phosphate (aka 3-phospho-D-glycerate, 3PG) is a metabolic intermediate of glucose, lipid and energy metabolism. Its cellular levels may be regulated by cytosolic glycerol-3-phosphate phosphatase (PGP aka G3PP), which hydrolyses 3PG to glycerol. PGP functions as a homodimer, binding one Mg2+ ion per subunit. The function of the human protein is inferred from rat Pgp characterisation and functional studies (Mugabo et al. 2016).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
glycerol-3-phosphatase activity of PGP:Mg2+ dimer [cytosol] PGP:Mg2+ dimer [cytosol] glycerol-3-phosphatase activity (0043136)
Inferred From