RBKS phosphorylates ribose to R5P

Stable Identifier
R-HSA-8955844
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In order for D-ribose to be incorporated into ATP or other high energy phosphorylated derivatives, ribose must first be converted into ribose-5-phosphate (R5P), which can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. Cytosolic ribokinase (RBKS) catalyses this reaction in the presence of ATP (Park et al. 2007). Other pentoses and simple sugars were either not or poorly phosphorylated by RBKS. RBKS belongs to the PfkB family of carbohydrate kinases which includes adenosine kinase (AK) and fructokinase. RBKS shares high structural similarity to AK and its catalytic mechanism is very similar to AK (Park & Gupta 2008).

Literature References
PubMed ID Title Journal Year
17585908 Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase

Park, J, van Koeverden, P, Singh, B, Gupta, RS

FEBS Lett. 2007
18560757 Adenosine kinase and ribokinase--the RK family of proteins

Park, J, Gupta, RS

Cell. Mol. Life Sci. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ribokinase activity of RBKS [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created