SOCS3 gene expression is inhibited by RUNX1

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R-HSA-8955885
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Reaction [omitted]
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Homo sapiens
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RUNX1, presumably in complex with CBFB, inhibits transcription of the SOCS3 gene. As SOCS3 is an inhibitor of STAT3, RUNX1-mediated repression of SOCS3 increases STAT3 activity, which is implicated in development of epithelial cancers (Scheitz et al. 2012).

Literature References
PubMed ID Title Journal Year
23034403 Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer

Scheitz, CJ, Lee, TS, McDermitt, DJ, Tumbar, T

EMBO J. 2012
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