Reactome | G76-NEDD8-K1881-CUL9 [cytosol]

G76-NEDD8-K1881-CUL9 [cytosol]

Stable Identifier

R-HSA-8955921

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cullin-9, CUL9_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IWT3 CUL9

Gene Names

CUL9, H7AP1, KIAA0708, PARC

Chain

chain:1-2517

Reference Genes

BioGPS Gene:23113 CUL9

COSMIC (genes):CUL9 CUL9

CTD Gene:23113 CUL9

dbSNP Gene:23113 CUL9

ENSEMBL:ENSG00000112659 CUL9

ENSEMBL:ENSG00000112659.14 CUL9

HGNC:15982 CUL9

KEGG Gene (Homo sapiens):23113 CUL9

Monarch:23113 CUL9

NCBI Gene:23113 CUL9

OMIM:607489 CUL9

UCSC:Q8IWT3 CUL9

Reference Transcript

RefSeq:NM_015089.3 CUL9

Other Identifiers

11755140_a_at

17008867

213204_PM_at

213204_at

23113

236392_PM_at

236392_at

2907755

2907757

2907759

2907760

2907761

2907762

2907763

2907764

2907765

2907767

2907769

2907770

2907772

2907773

2907774

2907776

2907777

2907779

2907781

2907782

2907784

2907785

2907788

2907789

2907791

2907792

2907794

2907795

2907796

2907798

2907799

2907800

2907805

2907806

2907808

2907809

2907810

2907811

2907812

2907813

2907814

2907815

2907817

2907819

2907821

2907823

2907825

2907827

2907829

2907830

2907831

2907832

2954381

2954385

2954408

41614_at

43123_at

8119722

A_23_P311740

GO:0000166

GO:0000226

GO:0000278

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006511

GO:0007010

GO:0007088

GO:0016567

GO:0016740

GO:0019538

GO:0030163

GO:0031461

GO:0031625

GO:0036211

GO:0046872

GO:0061630

GO:0140014

GO:0140096

HMNXSV003043136

Hs.117177.0.S1_3p_at

Hs.187631.0.A1_3p_at

ILMN_1806010

PH_hs_0024914

TC06000597.hg

Participates

as a component of

NEDD8-CUL9:RBX1 [cytosol] (Homo sapiens)

Other forms of this molecule

CUL9 [cytosol]

Inferred To

CUL9 [cytosol] (Bos taurus)

G76-NEDD8-K1881-CUL9 [cytosol] (Canis familiaris)

G76-NEDD8-K1881-CUL9 [cytosol] (Rattus norvegicus)

G76-NEDD8-K1881-CUL9 [cytosol] (Sus scrofa)

Modified Residues

Name

neddylated lysine (monoNEDD8 [cytosol]) at 1881

Coordinate

1881

Modification

monoNEDD8 [cytosol]

PsiMod Name

neddylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.

Cross References

RefSeq

NP_055904.1

OpenTargets

ENSG00000112659

GeneCards

Q8IWT3

HPA

ENSG00000112659-CUL9

Ensembl

ENST00000252050, ENSP00000252050, ENSG00000112659

PRO

Q8IWT3

Pharos - Targets

Q8IWT3

PDB

2JUF

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.85	7