AcM-UBE2M transfers NEDD8 to CUL9:RBX1

Stable Identifier
R-HSA-8956025
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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UBE2M transfers NEDD8 to lysine 1881 of CUL9 (Skaar et al, 2007; Li et al, 2014). Neddylation increases the ubiquitination activity of the E3 complex towards its targets (Hori et al, 1999; Duda et al, 2008). One defined target of CUL9 is BIRC5 (also known as Survivin), which has roles in cellular proliferation, inhibition of apoptosis and maintenance of genome stability (Zhao et al, 2000; Watanabe, 2010). CUL9-mediated ubiquitination of BIRC5 is negatively regulated by the 3M complex, consisting of CUL7, CCDC8 and OBSL1 (Li et al, 2014).

Literature References
PubMed ID Title Journal Year
10597293 Covalent modification of all members of human cullin family proteins by NEDD8

Hori, T, Osaka, F, Chiba, T, Miyamoto, C, Okabayashi, K, Shimbara, N, Kato, S, Tanaka, K

Oncogene 1999
17332328 PARC and CUL7 form atypical cullin RING ligase complexes

Skaar, JR, Florens, L, Tsutsumi, T, Arai, T, Tron, A, Swanson, SK, Washburn, MP, DeCaprio, JA

Cancer Res. 2007
24793696 CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity

Li, Z, Pei, XH, Yan, J, Yan, F, Cappell, KM, Whitehurst, AW, Xiong, Y

Mol. Cell 2014
21447816 Temporal and spatial regulation of targeting aurora B to the inner centromere

Watanabe, Y

Cold Spring Harb. Symp. Quant. Biol. 2010
11069780 The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner

Zhao, J, Tenev, T, Martins, LM, Downward, J, Lemoine, NR

J. Cell. Sci. 2000
18805092 Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

Duda, DM, Borg, LA, Scott, DC, Hunt, HW, Hammel, M, Schulman, BA

Cell 2008
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NEDD8 transferase activity of NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created