CUL9:RBX1 ubiquitinates BIRC5

Stable Identifier
R-HSA-8956026
Type
Reaction [transition]
Species
Homo sapiens
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One defined target of CUL9 ubiquitin ligase is BIRC5 (also known as Survivin), which has roles in cellular proliferation, inhibition of apoptosis and maintenance of genome stability (Zhao et al, 2000; Watanabe, 2010). Deletion of CUL9 leads to polyploidy, abnormal nuclear morphology and DNA damage and is accompanied by an increase in survivin protein levels (Li et al, 2014). CUL9-mediated ubiquitination of BIRC5 is negatively regulated by the 3M complex, consisting of CUL7, CCDC8 and OBSL1 (Li et al, 2014; Yan et al, 2014). This CUL7-dependent inhibition of CUL9 ubiquitin ligase activity is promoted by heterodimerization between CUL7 and CUL9 (Li et al, 2014).

Literature References
PubMed ID Title Journal Year
24793696 CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity

Li, Z, Pei, XH, Yan, J, Yan, F, Cappell, KM, Whitehurst, AW, Xiong, Y

Mol. Cell 2014
24793695 The 3M complex maintains microtubule and genome integrity

Yan, J, Yan, F, Li, Z, Sinnott, B, Cappell, KM, Yu, Y, Mo, J, Duncan, JA, Chen, X, Cormier-Daire, V, Whitehurst, AW, Xiong, Y

Mol. Cell 2014
21447816 Temporal and spatial regulation of targeting aurora B to the inner centromere

Watanabe, Y

Cold Spring Harb. Symp. Quant. Biol. 2010
11069780 The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner

Zhao, J, Tenev, T, Martins, LM, Downward, J, Lemoine, NR

J. Cell. Sci. 2000
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Catalyst Activity
Title
ubiquitin protein ligase activity of NEDD8-CUL9:RBX1 [cytosol]
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