Reactome | NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex

NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex

Stable Identifier

R-HSA-8956031

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex

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CUL9 (also known as PARC for p53-associated PARkin-like cytoplasmic protein) is an atypical cullin that has been shown to form a ubiquitin ligase complex with RBX1, although other components of the putative CRL9 complex have not yet been identified (Skaar et al, 2007; Li et al, 2014). CUL9:RBX1 is neddylated in vivo, likely through the UBE2M E2 although this hasn't been directly demonstrated (Skaar et al, 2007).
CUL9 is 60% identical to CUL7, another atypical mammalian cullin family member, but more distantly related to CUL1, 2, 3, 4A,4B and 5. CUL9 and CUL7 have been shown to form a heterodimer in vivo, and both interact with p53 (Skaar et al, 2007; Andrews et al, 2006; Nikolaev et al, 2003). CUL9 ubiquitinates BIRC5 (also known as Survivin), a protein with roles in cellular proliferation and inhibition of apoptosis. CUL9-mediated ubiquitination of BIRC5 is inhibited by the 3M complex, which consists of CUL7, CCDC8 and OBSL1 (Li et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
12526791	Parc: a cytoplasmic anchor for p53 Gu, W, Nikolaev, AY, Qin, J, Puskas, N, Li, M	Cell	2003
17332328	PARC and CUL7 form atypical cullin RING ligase complexes Tron, A, Florens, L, Tsutsumi, T, Skaar, JR, Swanson, SK, Arai, T, DeCaprio, JA, Washburn, MP	Cancer Res.	2007
16547496	Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function He, YJ, Andrews, P, Xiong, Y	Oncogene	2006
24793696	CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity Pei, XH, Yan, J, Li, Z, Xiong, Y, Yan, F, Cappell, KM, Whitehurst, AW	Mol. Cell	2014