NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex

Stable Identifier
R-HSA-8956031
Type
Reaction [binding]
Species
Homo sapiens
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CUL9 (also known as PARC for p53-associated PARkin-like cytoplasmic protein) is an atypical cullin that has been shown to form a ubiquitin ligase complex with RBX1, although other components of the putative CRL9 complex have not yet been identified (Skaar et al, 2007; Li et al, 2014). CUL9:RBX1 is neddylated in vivo, likely through the UBE2M E2 although this hasn't been directly demonstrated (Skaar et al, 2007).
CUL9 is 60% identical to CUL7, another atypical mammalian cullin family member, but more distantly related to CUL1, 2, 3, 4A,4B and 5. CUL9 and CUL7 have been shown to form a heterodimer in vivo, and both interact with p53 (Skaar et al, 2007; Andrews et al, 2006; Nikolaev et al, 2003). CUL9 ubiquitinates BIRC5 (also known as Survivin), a protein with roles in cellular proliferation and inhibition of apoptosis. CUL9-mediated ubiquitination of BIRC5 is inhibited by the 3M complex, which consists of CUL7, CCDC8 and OBSL1 (Li et al, 2014).

Literature References
PubMed ID Title Journal Year
17332328 PARC and CUL7 form atypical cullin RING ligase complexes

Skaar, JR, Florens, L, Tsutsumi, T, Arai, T, Tron, A, Swanson, SK, Washburn, MP, DeCaprio, JA

Cancer Res. 2007
12526791 Parc: a cytoplasmic anchor for p53

Nikolaev, AY, Li, M, Puskas, N, Qin, J, Gu, W

Cell 2003
16547496 Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function

Andrews, P, He, YJ, Xiong, Y

Oncogene 2006
24793696 CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity

Li, Z, Pei, XH, Yan, J, Yan, F, Cappell, KM, Whitehurst, AW, Xiong, Y

Mol. Cell 2014
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