VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7

Stable Identifier
R-HSA-8956099
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The best characterized CRL2 substrate binding F-box protein is the von Hippel- Lindau (VHL) tumor suppressor, which targets the alpha subunit of hypoxia inducible factor (HIFalpha) for ubiquitination and degradation through VCP/p97 and the 26 S proteasome (Sufan and Ohh, 2006; Heir et al, 2013; reviewed in Cai and Yang, 2016). UBXN7 is an adapter that binds to neddylated CUL2 and interferes with the ability of the CUL2:EloB:EloC:VHL E3 ubiquitin ligase complex to ubiquitinate HIF alpha, in this way causing accumulation of HIF alpha (Bandau et al, 2012; Den Besten et al, 2012)

Participants
Participant Of
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Orthologous Events