VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha

Stable Identifier
R-HSA-8956106
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

VHL is the substrate binding protein of a CUL2-based E3 ubiquitin ligase complex that conjugates ubiquitin to hydroxylated HIF-alpha (Iwai et al. 1999, Kamura et al. 2000, Ohh et al. 2000, Groulx and Lee 2002, Maynard et al. 2003). VHL is predominantly cytosolic and shuttles between the cytosol and the nucleus (Lee et al. 1999, Groulx and Lee 2002). Ubiquitination and degradation of HIF-alpha can occur in both the cytosol and the nucleus (Berra et al. 2001). Upon return to normoxia from hypoxia most ubiquitinated HIF-alpha is nuclear (Groulx and Lee 2002).

Participants
Participant Of
hasEvent
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]
Physical Entity
Activity
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Orthologous Events