Reactome | NEDD8 and UBD bind NUB1 and the 26S proteasome

NEDD8 and UBD bind NUB1 and the 26S proteasome

Stable Identifier

R-HSA-8956140

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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NEDD8 and UBD bind NUB1 and the 26S proteasome

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NEDD8 ultimate buster 1 (NUB1) is a negative regulator of the NEDD8 conjugation system. NUB1 interacts with NEDD8 and another ubiquitin-like modifier, UBD (also known as FAT10) to promote their degradation and that of their conjugated proteins (Kito et al, 2001; Kamitani et al, 2001; Hipp et al, 2004; Schmidtke et al, 2006). NUB1 interacts directly with both NEDD8/UBD and with PMSD4, a subunit of the 19S cap of the 26S proteasome, through a ubiquitin-like domain (UBL), and in this way promotes the contact between the proteasome and its substrate (Kito et al, 2001; Kamitani et al, 2001; Hipp et al, 2004; Tanji et al, 2005; Schmidtke et al, 2006; reviewed in Tanaka et al, 2012; Schmidtke et al, 2014). There are two isoforms of NUB1 in human cells that differ by the presence of a 14 amino acid insertion in the NUB1L. NUB1L promotes the degradation of NEDD8 more efficiently than the short isoform (Tanaka et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
11585840	Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1 Kito, K, Fukuda-Kamitani, T, Yeh, ET, Kamitani, T	J. Biol. Chem.	2001
11259415	NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression Kito, K, Kamitani, T, Yeh, ET	J. Biol. Chem.	2001
14757770	NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation Groettrup, M, Raasi, S, Hipp, MS, Schmidtke, G	J. Biol. Chem.	2004
12816948	Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L Yeh, ET, Tanaka, T, Kawashima, H, Kamitani, T	J. Biol. Chem.	2003
16171779	Interaction of NUB1 with the proteasome subunit S5a Tanaka, T, Tanji, K, Kamitani, T	Biochem. Biophys. Res. Commun.	2005
16707496	The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10 Groettrup, M, Hipp, MS, Schmidtke, G, Kalveram, B, Lukasiak, S, Bochtler, P, Weber, E	J. Biol. Chem.	2006
22306028	Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy Tanaka, T, Nakatani, T, Kamitani, T	Mol Oncol	2012
23333871	FAT10ylation as a signal for proteasomal degradation Aichem, A, Groettrup, M, Schmidtke, G	Biochim. Biophys. Acta	2014