Reactome | LMO2 [nucleoplasm]

LMO2 [nucleoplasm]

Stable Identifier

R-HSA-8956513

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Rhombotin-2, RBTN2_HUMAN, RBTN2, RBTNL1, RHOM2, TTG2, LIM domain only protein 2, T-cell translocation protein 2

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
        
        MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)
        
        RUNX1 binds the core TAL1 complex (Homo sapiens)
        
        RUNX1:CBFB:TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)
        
        RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25791 LMO2

Gene Names

LMO2, RBTN2, RBTNL1, RHOM2, TTG2

Chain

chain:1-158

Reference Genes

BioGPS Gene:4005 LMO2

COSMIC (genes):LMO2 LMO2

CTD Gene:4005 LMO2

dbSNP Gene:4005 LMO2

ENSEMBL:ENSG00000135363 LMO2

ENSEMBL:ENSG00000135363.12 LMO2

HGNC:6642 LMO2

KEGG Gene (Homo sapiens):4005 LMO2

Monarch:4005 LMO2

NCBI Gene:4005 LMO2

OMIM:180385 LMO2

UCSC:P25791 LMO2

Reference Transcript

Other Identifiers

11730469_s_at

16737244

204249_PM_s_at

204249_s_at

32184_at

3368815

3368816

3368825

3368826

3368827

3368835

3368836

3368837

3368838

3368839

3368840

3368841

3368849

3368857

3368858

3368859

4005

7947450

A_23_P53126

GE79375

GO:0001221

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0006351

GO:0006355

GO:0042802

GO:0043226

GO:0043425

GO:0045944

GO:0046872

GO:0061629

GO:0097067

GO:0140110

GO:0140297

HMNXSV003033140

Hs.128746.0.S1_3p_at

PH_hs_0032478

TC11001543.hg

X61118_rna1_at

g6633806_3p_a_at

Participates

as a member of

LMO1,LMO2 [nucleoplasm] (Homo sapiens)

Inferred To

Bx [nucleoplasm] (Drosophila melanogaster)

Lmo2 [nucleoplasm] (Mus musculus)

Lmo2 [nucleoplasm] (Rattus norvegicus)

lmo2 [nucleoplasm] (Danio rerio)

LMO2 [nucleoplasm] (Bos taurus)

LMO2 [nucleoplasm] (Gallus gallus)

LMO2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_005252978.1, NP_005565.2, XP_016873222.1, XP_016873220.1, NP_001135787.1, XP_016873218.1, NP_001135788.1, XP_016873221.1, XP_016873216.1, XP_016873219.1, XP_016873217.1

OpenTargets

ENSG00000135363

GeneCards

P25791

HPA

ENSG00000135363-LMO2

Ensembl

ENSG00000135363, ENSP00000379175, ENST00000411482, ENST00000257818, ENSP00000257818, ENST00000395833, ENSP00000401967

ZINC target

P25791

PRO

P25791

Pharos - Targets

P25791

PDB

2YPA, 2XJZ, 4KFZ, 2XJY

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.666	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.556	3
UniProt:Q13464 ROCK1	6	ROCK1 [extracellular region] (R-HSA-6806527) ROCK1 [secretory granule lumen] (R-HSA-6804967) ROCK1(1114-1354) [cytosol] (R-HSA-212524) ROCK1(1-1113) [cytosol] (R-HSA-212523) Activated ROCK1 [cytosol] (R-HSA-4687777) ROCK1 [cytosol] (R-HSA-212509)	0.556	3
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q96FT9 IFT43	2	IFT43 [cilium] (R-HSA-5617619) IFT43 [ciliary tip] (R-HSA-5625348)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.556	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.543	3