RUNX1-containing TAL1 complex binds the MYB gene enhancer

Stable Identifier
R-HSA-8956586
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The TAL1 complex containing GATA3, RUNX1 and CBFB binds the MYB gene enhancer element (Sanda et al. 2012, Mansour et al. 2014). Binding of the RUNX1-containing TAL1 complex to the MYB gene enhancer can be facilitated by the presence of the MYB transcription factor (Mansour et al. 2014).

Literature References
PubMed ID Title Journal Year
22897851 Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia

Sanda, T, Lawton, LN, Barrasa, MI, Fan, ZP, Kohlhammer, H, Gutierrez, A, Ma, W, Tatarek, J, Ahn, Y, Kelliher, MA, Jamieson, CH, Staudt, LM, Young, RA, Look, AT

Cancer Cell 2012
25394790 Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Mansour, MR, Abraham, BJ, Anders, L, Berezovskaya, A, Gutierrez, A, Durbin, AD, Etchin, J, Lawton, L, Sallan, SE, Silverman, LB, Loh, ML, Hunger, SP, Sanda, T, Young, RA, Look, AT

Science 2014
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