RUNX1 binds YAP1

Stable Identifier
R-HSA-8956639
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RUNX1, presumably in complex with CBFB, binds to YAP1 (Levy, Adamovich et al. 2008; Levy, Reuven and Shaul 2008). Phosphorylation of YAP1 by ABL1 in response to DNA damage prevents binding of YAP1 to RUNX1 (Levy, Adamovich et al. 2008).

Literature References
PubMed ID Title Journal Year
18280240 Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

Levy, D, Adamovich, Y, Reuven, N, Shaul, Y

Mol. Cell 2008
18701449 A regulatory circuit controlling Itch-mediated p73 degradation by Runx

Levy, D, Reuven, N, Shaul, Y

J. Biol. Chem. 2008
Participants
Participant Of
This event is regulated
Orthologous Events
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