ABL1 phosphorylates YAP1

Stable Identifier
R-HSA-8956659
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In response to DNA damage, ABL1 phosphorylates YAP1 on tyrosine residue Y407 (corresponds to Y357 in the YAP1 splicing isoform 3, known as YAP1-1beta, which was used in the study by Levy, Adamovich et al. 2008).

Literature References
PubMed ID Title Journal Year
18280240 Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

Levy, D, Adamovich, Y, Reuven, N, Shaul, Y

Mol. Cell 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-S456-ABL1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created