YAP1 binds TP73

Stable Identifier
R-HSA-8956676
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

YAP1, phosphorylated on tyrosine residue Y407 (Y357 in the splicing isoform 3, known as YAP1-1beta) by the protein tyrosine kinase ABL1, activated in response to DNA damage, forms a complex with TP73. ABL1-phosphorylated YAP1 can no longer bind RUNX1 (Levy, Adamovich et al. 2008; Levy, Reuven and Shaul 2008). Binding of phosphorylated YAP1 to TP73 may target TP73 to promoters of pro-apoptotic target genes instead of cell cycle arrest genes (Levy, Adamovich et al. 2008).

Literature References
PubMed ID Title Journal Year
18280240 Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

Levy, D, Adamovich, Y, Reuven, N, Shaul, Y

Mol. Cell 2008
18701449 A regulatory circuit controlling Itch-mediated p73 degradation by Runx

Levy, D, Reuven, N, Shaul, Y

J. Biol. Chem. 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created