ITCH polyubiquitinates TP73

Stable Identifier
R-HSA-8956684
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The E3 ubiquitin-protein ligase ITCH polyubiquitinates TP73 (p73), targeting it for degradation. In response to DNA damage, ITCH levels are downregulated, allowing TP73 to accumulate (Rossi et al. 2005). Downregulation of ITCH in response to DNA damage is the consequence of DNA damage-induced phosphorylation of YAP1 by ABL1. YAP1 phosphorylated by ABL1 is no longer able to bind to RUNX1, and the complex of RUNX1 and YAP1 is needed for transcription of the ITCH gene (Levy, Reuven and Shaul 2008).

Literature References
PubMed ID Title Journal Year
15678106 The ubiquitin-protein ligase Itch regulates p73 stability

Rossi, M, De Laurenzi, V, Munarriz, E, Green, DR, Liu, YC, Vousden, KH, Cesareni, G, Melino, G

EMBO J. 2005
18701449 A regulatory circuit controlling Itch-mediated p73 degradation by Runx

Levy, D, Reuven, N, Shaul, Y

J. Biol. Chem. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of ITCH [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created