Reactome | IGFBP1 [endoplasmic reticulum lumen]

IGFBP1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956699

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Insulin-like growth factor-binding protein 1, IBP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08833 IGFBP1

Gene Names

IGFBP1, IBP1

Chain

signal peptide:1-25, chain:26-259

Reference Genes

BioGPS Gene:3484 IGFBP1

COSMIC (genes):IGFBP1 IGFBP1

CTD Gene:3484 IGFBP1

dbSNP Gene:3484 IGFBP1

ENSEMBL:ENSG00000146678 IGFBP1

HGNC:5469 IGFBP1

KEGG:hsa:3484 IGFBP1

Monarch:3484 IGFBP1

NCBI Gene:3484 IGFBP1

OMIM:146730 IGFBP1

UCSC:P08833 IGFBP1

Reference Transcript

RefSeq:NM_000596.2 IGFBP1

Other Identifiers

11717473_s_at

1232_s_at

17045838

205302_PM_at

205302_at

3000516

3000517

3000518

3000519

3000521

3000522

3000524

3000526

3000527

3484

8132694

A_23_P42868

GE508365

GO:0005102

GO:0005515

GO:0005520

GO:0005576

GO:0005615

GO:0005788

GO:0005794

GO:0007165

GO:0008286

GO:0014070

GO:0019838

GO:0030307

GO:0031994

GO:0031995

GO:0032868

GO:0042246

GO:0043226

GO:0043567

GO:0048856

GO:0090090

HMNXSV003028591

ILMN_1728445

ILMN_2387385

M74587_rna1_s_at

PH_hs_0019089

TC07000294.hg

g4504614_3p_at

Participates

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

IGFBP1 [extracellular region]

p-IGFBP1 [endoplasmic reticulum lumen]

Inferred To

IGFBP1 [endoplasmic reticulum lumen] (Bos taurus)

IGFBP1 [endoplasmic reticulum lumen] (Gallus gallus)

IGFBP1 [endoplasmic reticulum lumen] (Sus scrofa)

Igfbp1 [endoplasmic reticulum lumen] (Mus musculus)

Igfbp1 [endoplasmic reticulum lumen] (Rattus norvegicus)

igfbp1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_000587.1

ENSEMBL

ENSP00000275525

OpenTargets

ENSG00000146678

HPA

ENSG00000146678-IGFBP1

ZINC - Substances

IBP1_HUMAN

ZINC target

P08833

PRO

P08833

Pharos - Targets

P08833

PDB

2DSQ, 1ZT5, 1ZT3

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05019 IGF1	2	IGF1 [extracellular region] (R-HSA-2404178) IGF1 [platelet alpha granule lumen] (R-HSA-139878)	0.623	2
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q9H7X3 ZNF696	1	ZNF696 [nucleoplasm] (R-HSA-2454138)	0.527	2
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.527	2
UniProt:Q6UX71 PXDC2			0.527	2
UniProt:P26045 PTPN3	3	PTPN3 [cytosol] (R-HSA-8867650) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [plasma membrane] (R-HSA-5490317)	0.527	2
UniProt:Q9UHI8 ADAMTS1	4	ADAMTS1 [extracellular region] (R-HSA-3791292) ADAMTS1 [endoplasmic reticulum lumen] (R-HSA-5173121) glc-fuc-ADAMTS1 [endoplasmic reticulum lumen] (R-HSA-5173006) O-fuc-ADAMTS1 [endoplasmic reticulum lumen] (R-HSA-5172971)	0.527	2
UniProt:O60279 SUSD5			0.527	2
UniProt:Q15654 TRIP6			0.527	2
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.527	2
UniProt:P01033 TIMP1	4	TIMP1 [platelet alpha granule lumen] (R-HSA-349745) p-TIMP1 [endoplasmic reticulum lumen] (R-HSA-8957082) TIMP1 [endoplasmic reticulum lumen] (R-HSA-8956691) TIMP1 [extracellular region] (R-HSA-349743)	0.527	2

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