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IGFBP4 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8956754
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Insulin-like growth factor-binding protein 4, IBP4_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
IGFBP4 [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
IGFBP4 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22692 IGFBP4
Gene Names
IGFBP4, IBP4
Chain
signal peptide:1-21, chain:22-258
Reference Genes
BioGPS Gene:3487 IGFBP4
COSMIC (genes):IGFBP4 IGFBP4
CTD Gene:3487 IGFBP4
dbSNP Gene:3487 IGFBP4
ENSEMBL:ENSG00000141753 IGFBP4
ENSEMBL_homo_sapiens_GENE:ENSG00000141753.7 IGFBP4
HGNC:5473 IGFBP4
KEGG Gene (Homo sapiens):3487 IGFBP4
Monarch:3487 IGFBP4
NCBI Gene:3487 IGFBP4
OMIM:146733 IGFBP4
UCSC:P22692 IGFBP4
Reference Transcript
RefSeq:NM_001552.2 IGFBP4
Other Identifiers
11715463_s_at
11715464_x_at
11715465_at
11749616_s_at
16834091
1737_s_at
201508_PM_at
201508_at
3487
3721011
3721012
3721028
3721030
3721032
3721033
3721034
3721037
39781_at
74566_at
8007100
89974_at
A_14_P139973
A_24_P382187
GE81040
GE86806
GO:0000165
GO:0001558
GO:0005102
GO:0005515
GO:0005520
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005975
GO:0007165
GO:0010906
GO:0014070
GO:0019838
GO:0023052
GO:0031994
GO:0031995
GO:0040008
GO:0043226
GO:0043410
GO:0043567
GO:0043568
GO:0044342
GO:0090090
HMNXSV003003979
ILMN_1665865
M62403_s_at
PH_hs_0000202
TC17000499.hg
g10835020_3p_s_at
Participates
as a member of
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
IGFBP4 [extracellular region]
IGFBP4(157-237) [extracellular region]
IGFBP4(22-156) [extracellular region]
p-IGFBP4 [endoplasmic reticulum lumen]
Inferred To
IGFBP4 [endoplasmic reticulum lumen]
(Bos taurus)
IGFBP4 [endoplasmic reticulum lumen]
(Canis familiaris)
IGFBP4 [endoplasmic reticulum lumen]
(Gallus gallus)
IGFBP4 [endoplasmic reticulum lumen]
(Sus scrofa)
Igfbp4 [endoplasmic reticulum lumen]
(Mus musculus)
Igfbp4 [endoplasmic reticulum lumen]
(Rattus norvegicus)
igfbp4 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001543.2
OpenTargets
ENSG00000141753
HPA
ENSG00000141753-IGFBP4
ZINC - Substances
IBP4_HUMAN
GeneCards
P22692
ZINC target
P22692
Ensembl
ENSP00000269593
,
ENSG00000141753
,
ENST00000269593
PRO
P22692
Pharos - Targets
P22692
PDB
1WQJ
,
2DSR
,
2DSP
,
2DSQ
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05019 IGF1
2
IGF1 [platelet alpha granule lumen]
(R-HSA-139878)
IGF1 [extracellular region]
(R-HSA-2404178)
0.76
7
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:O14901 KLF11
0.556
3
UniProt:O14656 TOR1A
1
TOR1A [cytosol]
(R-HSA-8862858)
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:P01344 IGF2
2
IGF2(25-91) [platelet alpha granule lumen]
(R-HSA-3006322)
IGF2(25-91) [extracellular region]
(R-HSA-2404175)
0.483
3
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