26S proteasome degrades TP73 polyubiquitinated by ITCH

Stable Identifier
R-HSA-8957265
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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ITCH-mediated polyubiquitination of TP73 (p73) targets TP73 for proteasome-mediated degradation (Rossi et al. 2005).

Literature References
PubMed ID Title Journal Year
15678106 The ubiquitin-protein ligase Itch regulates p73 stability

Rossi, M, De Laurenzi, V, Munarriz, E, Green, DR, Liu, YC, Vousden, KH, Cesareni, G, Melino, G

EMBO J. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created